PMID

Data

Article Title

Organization

Synthesis and structure-activity relationships of 2-substituted D-tryptophan-containing peptidic endothelin receptor antagonists: importance of the C-2 substituent of the D-tryptophan residue for endothelin A and B receptor subtype selectivity.

Tsukuba Research Institute

Endothelin: a new challenge.

Warner-Lambert

Endothelin antagonists: discovery of EMD 122946, a highly potent and orally active ETA selective antagonist.

Merck

 

IRL 2500: A potent ETB selective endothelin antagonist

TBA

 

Synthesis of 2-substituted d-tryptophan-containing peptide derivatives with endothelin receptor antagonist activity

TBA

 

Pyridazinones with a pendant acylsulfonamide moiety as endothelin receptor antagonists

TBA

Structure-activity relationships of a novel class of endothelin-A receptor antagonists and discovery of potent and selective receptor antagonist, 2-(benzo[1,3]dioxol-5-yl)-6-isopropyloxy-4-(4-methoxyphenyl)-2H-chromene-3-carboxylic acid (S-1255). 1. Study on structure-activity relationships and bas

Shionogi

Peptoids as endothelin receptor antagonists.

Ranbaxy Laboratories

Discovery and synthesis of a potent sulfonamide ET(B) selective antagonist.

Shionogi

From bosentan (TracleerŪ) to macitentan (OpsumitŪ): The medicinal chemistry perspective.

Actelion Pharmaceuticals

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 2. Sulfonamide-based ETA/ETB mixed antagonists.

Abbott Laboratories

Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists.

Abbott Laboratories

2,4-Diarylpyrrolidine-3-carboxylic acids--potent ETA selective endothelin receptor antagonists. 1. Discovery of A-127722.

Abbott Laboratories

Azole endothelin antagonists. 2. Structure-activity studies.

Abbott Laboratories

Azole endothelin antagonists. 1. A receptor model explains an unusual structure-activity profile.

Abbott Laboratories

Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists.

Tsukuba Research Institute