PMID

Data

Article Title

Organization

Amino Acid Thioester Derivatives: A Highly Promising Scaffold for the Development of Metallo-ß-lactamase L1 Inhibitors.

North-West University

The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-ß-lactamases and arginases.

The University of Queensland

Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.

F. Hoffmann-La Roche

Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.

Wyeth Research

Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.

Wyeth Research

Mechanism of inactivation of beta-lactamases by novel 6-methylidene penems elucidated using electrospray ionization mass spectrometry.

Wyeth Research

Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.

Wyeth-Ayerst Research

Structure-activity relationships of biphenyl tetrazoles as metallo-beta-lactamase inhibitors.

Merck Research Laboratories