49 articles for thisTarget
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Article Title
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Discovery of a novel covalent non-ß-lactam inhibitor of the metallo-ß-lactamase NDM-1.
Uit The Arctic University of Norway
Triazolylthioacetamide: A Valid Scaffold for the Development of New Delhi Metallo-ß-Lactmase-1 (NDM-1) Inhibitors.
North-West University
Fragment-based discovery of inhibitor scaffolds targeting the metallo-ß-lactamases NDM-1 and VIM-2.
Uit The Arctic University of Norway
Amino Acid Thioester Derivatives: A Highly Promising Scaffold for the Development of Metallo-ß-lactamase L1 Inhibitors.
North-West University
The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-ß-lactamases and arginases.
The University of Queensland
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.
F. Hoffmann-La Roche
Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases.
University of Li£Ge
Design, synthesis and antibacterial activity evaluation of ebselen derivatives in NDM-1 producing bacteria.
Ocean University of China
Exploiting the Carboxylate-Binding Pocket of β-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library.
Baylor College of Medicine
Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.
University of the Republic (UdelaR)
Discovery of hydroxamate as a promising scaffold dually inhibiting metallo- and serine-β-lactamases.
Northwest University
Fluorinated captopril analogues inhibit metallo-β-lactamases and facilitate structure determination of NDM-1 binding pose.
UiT The Arctic University of Norway
The activity and mechanism of vidofludimus as a potent enzyme inhibitor against NDM-1-positive E. coli.
Northeast Agricultural University
Kinetics, Thermodynamics, and Structural Effects of Quinoline-2-Carboxylates, Zinc-Binding Inhibitors of New Delhi Metallo-β-lactamase-1 Re-sensitizing Multidrug-Resistant Bacteria for Carbapenems.
Freie University Berlin
Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance.
The University of Queensland
Design, Synthesis, and Biological Evaluation of New 1H-Imidazole-2-Carboxylic Acid Derivatives as Metallo-β-Lactamase Inhibitors.
Xihua University
Aurones and derivatives as promising New Delhi metallo-β-lactamase (NDM-1) inhibitors.
Univ. Grenoble Alpes
Small-molecule inhibitors of bacterial-producing metallo-β-lactamases: insights into their resistance mechanisms and biochemical analyses of their activities.
University Sains Malaysia
Recent advances in β-lactamase inhibitor chemotypes and inhibition modes.
Xihua University
α-Aminophosphonate inhibitors of metallo-β-lactamases NDM-1 and VIM-2.
Uppsala University
1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors.
Cnrs
Optimized Ebselen-Based Inhibitors of Bacterial Ureases with Nontypical Mode of Action.
Wroclaw University
Synthesis of novel ciprofloxacin-avibactam conjugates for the development of second-generation non-β-lactam-β-lactamase inhibitors.
CSIR-Institute of Himalayan Bioresource Technology
Crystal Structures of Metallo-β-Lactamase (IMP-1) and Its D120E Mutant in Complexes with Citrate and the Inhibitory Effect of the Benzyl Group in Citrate Monobenzyl Ester.
Kumamoto University
Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.
Wyeth Research
Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.
Wyeth Research
Mechanism of inactivation of beta-lactamases by novel 6-methylidene penems elucidated using electrospray ionization mass spectrometry.
Wyeth Research
Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases.
Southern Methodist University
Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases.
Northwest University
Investigation of synergistic antimicrobial effects of the drug combinations of meropenem and 1,2-benzisoselenazol-3(2H)-one derivatives on carbapenem-resistant Enterobacteriaceae producing NDM-1.
The Hong Kong Polytechnic University
Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.
Wyeth-Ayerst Research
Structure-activity relationships of biphenyl tetrazoles as metallo-beta-lactamase inhibitors.
Merck Research Laboratories
3-mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-β-lactamase inhibitors.
The University of Queensland
Synthesis and kinetic testing of new inhibitors for a metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa.
Helwan University
NOTA analogue: A first dithiocarbamate inhibitor of metallo-β-lactamases.
Zhengzhou University
Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases.
University of Oxford
Structure-activity relationship study and optimisation of 2-aminopyrrole-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile as a broad spectrum metallo-β-lactamase inhibitor.
The University of Queensland
Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-β-lactamase-1.
University of California San Diego
JAK kinase inhibitor compounds for treatment of respiratory disease
Theravance Biopharma R&D Ip
Flavanone derivatives, and preparation method and use thereof
Xuanwu Hospital of Capital Medical University
Glutathione transferase from Plasmodium falciparum--interaction with malagashanine and selected plant natural products.
University of Zimbabwe
Tyrosinase inhibitory effect of benzoic acid derivatives and their structure-activity relationships.
Yonsei University