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110 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Virtual screening and experimental validation identify novel modulators of nuclear receptor RXRa from Drugbank database.EBI
Xiamen University
Discovery of Highly Potent Liver X Receptor▀ Agonists.EBI
Bristol-Myers Squibb Co.
Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARa Selective Agonist.EBI
Bristol-Myers Squibb Co.
Binding characterization, synthesis and biological evaluation of RXRa antagonists targeting the coactivator binding site.EBI
Xiamen University
Identification of potent and selective retinoic acid receptor gamma (RAR┐) antagonists for the treatment of osteoarthritis pain using structure based drug design.EBI
Eli Lilly and Company
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR)▀ Agonist.EBI
Vitae Pharmaceuticals Inc
Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation.EBI
University of Gothenburg
SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR┐ Inhibitor.EBI
Central Pharmaceutical Research Institute
Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers.EBI
University of Alabama at Birmingham
Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid x receptor agonists.EBI
Okayama University Graduate School of Medicine
Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene.EBI
Aichi Gakuin University
Small molecule inhibitors targeting activator protein 1 (AP-1).EBI
University of Texas Medical Branch
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for ROR▀ and ROR┐t.EBI
Phenex Pharmaceuticals AG
Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity.EBI
University of Alabama at Birmingham
Synthesis and SAR study of modulators inhibiting tRXRa-dependent AKT activation.EBI
Xiamen University
Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency.EBI
Okayama University Graduate School of Medicine
Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential.EBI
Purdue University
Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents.EBI
The University of Illinois at Chicago
RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists.EBI
TBA
Discovery of a Potent Retinoid X Receptor Antagonist Structurally Closely Related to RXR Agonist NEt-3IB.EBI
TBA
Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents.EBI
Johnson & Johnson Pharmaceutical Research and Development LLC
Cytosporone B is an agonist for nuclear orphan receptor Nur77.EBI
Xiamen University
Modification at the Lipophilic Domain of RXR Agonists Differentially Influences Activation of RXR Heterodimers.EBI
TBA
Fluorescent retinoid X receptor ligands for fluorescence polarization assay.EBI
Okayama University
Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation.EBI
Okayama University
Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor.EBI
Aichi Gakuin University
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.EBI
Phenex Pharmaceuticals AG
Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).EBI
Arizona State University
 
Synthesis and structure-activity relationships of potent conformationally restricted retinoid X receptor ligandsEBI
TBA
 
Synthesis and structure-activity relationships of potent retinoid X receptor ligandsEBI
TBA
 
Synthesis of highly potent RXR-specific retinoids: The use of a cyclopropyl group as a double bond isostereEBI
TBA
 
Synthesis and pharmacological activity of conformationally restricted, acetylenic retinoid analogsEBI
TBA
 
Differential RXR & RAR activity of stilbene retinoid analogs bearing thiazole and imidazole carboxylic acidsEBI
TBA
 
Structural basis for the differential RXR & RAR activity of stilbene retinoid analogsEBI
TBA
Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity.EBI
Okayama University Graduate School of Medicine
Synthesis and structure-activity relationship of RXR antagonists based on the diazepinylbenzoic acid structure.EBI
Tsukuba Research Institute
Synthesis and structure-activity relationship of novel RXR antagonists: orally active anti-diabetic and anti-obesity agents.EBI
Tsukuba Research Institute
Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia.EBI
Johnson and Johnson Pharmaceutical Research and Development
RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia.EBI
Johnson and Johnson Pharmaceutical Research and Development
Aza-retinoids as novel retinoid X receptor-specific agonists.EBI
Ligand Pharmaceuticals Inc
Ligand recognition by RAR and RXR receptors: binding and selectivity.EBI
Universidad de Santiago de Compostela
Determinants of retinoid X receptor transcriptional antagonism.EBI
Institute
Design and synthesis of benzofused heterocyclic RXR modulators.EBI
Eli Lilly and Company
Structure-based design of potent retinoid X receptor alpha agonists.EBI
GlaxoSmithKline
Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics.EBI
Goethe-University Frankfurt
Design, synthesis and structure-activity relationship of novel RXR-selective modulators.EBI
Ligand Pharmaceuticals Inc
Design and synthesis of novel RXR-selective modulators with improved pharmacological profile.EBI
Ligand Pharmaceuticals Inc
Design and synthesis of fluorinated RXR modulators.EBI
Eli Lilly and Company
Convenient Retinoid X Receptor Binding Assay Based on Fluorescence Change of the Antagonist NEt-C343.EBI
Okayama University Graduate School of Medicine
Discovery of a "Gatekeeper" Antagonist that Blocks Entry Pathway to Retinoid X Receptors (RXRs) without Allosteric Ligand Inhibition in Permissive RXR Heterodimers.EBI
Okayama University Graduate School of Medicine
Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes.EBI
Ligand Pharmaceuticals Inc
The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470).EBI
Lilly Research Laboratories
Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid.EBI
Ligand Pharmaceuticals Inc
A New FXR Ligand Chemotype with Agonist/Antagonist Switch.EBI
Goethe-University Frankfurt
Creation of Fluorescent RXR Antagonists Based on CBTF-EE and Application to a Fluorescence Polarization Binding Assay.EBI
Okayama University Graduate School of Medicine
Synthesis and characterization of a new RXR agonist based on the 6-tert-butyl-1,1-dimethylindanyl structure.EBI
Universidade de Vigo
An improved synthesis of the C-linked glucuronide of N-(4-hydroxyphenyl)retinamide.EBI
The Ohio State University
Discovery of new LXR? agonists as glioblastoma inhibitors.EBI
Sun Yat-Sen University
Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities.EBI
Takeda Chemical Industries, Ltd
Discovery of 3?,7?,11?-Trihydroxy-6?-ethyl-5?-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders.EBI
TES Pharma S.r.l.
l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPAR?.EBI
Goethe-University Frankfurt
Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.EBI
Allergan Inc
Structure-Activity Relationship Study Enables the Discovery of a Novel EBI
Xiamen University
Discovery of Second Generation ROR? Inhibitors Composed of an Azole Scaffold.EBI
Kyoto Prefectural University of Medicine
Non-canonical modulators of nuclear receptors.EBI
Vitae Pharmaceuticals, Inc.
3H-Imidazo[4,5-b]pyridine-6-carboxylic acid derivatives as rexinoids with reduced teratogenicity.EBI
Okayama University Graduate School of Medicine
Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN).EBI
Arizona State University
Design, synthesis and biological evaluation of tetrazole-containing RXR? ligands as anticancer agents.EBI
Xiamen University
Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening.EBI
Okayama University Graduate School of Medicine
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation.EBI
Goethe University Frankfurt
Structure-activity relationship studies of novel heteroretinoids: induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid.EBI
Università di Ferrara
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.EBI
Genomics Institute of the Novartis Research Foundation (GNF)
Stereoselective synthesis and receptor activity of conformationally defined retinoid X receptor selective ligands.EBI
Allergan Inc
Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells.EBI
Ligand Pharmaceuticals Inc
Synthesis and characterization of heteroarotinoids demonstrate structure specificity relationships.EBI
University of Oklahoma Health Sciences Center
Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype.EBI
Goethe-University Frankfurt
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.EBI
University of Tokyo
Discovery of potent and selective PPAR?/? dual antagonists and initial biological studies.EBI
Inception Sciences
Structure-Based and Property-Driven Optimization of EBI
Global Discovery Chemistry
Cytotoxic Components from Hypericum elodeoides Targeting RXR? and Inducing HeLa Cell Apoptosis through Caspase-8 Activation and PARP Cleavage.EBI
Xiamen University
Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity.EBI
University of Alabama at Birmingham
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.EBI
Allergan Inc
A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences.EBI
Goethe-University Frankfurt
Identification of the first retinoid X, receptor homodimer antagonist.EBI
Ligand Pharmaceuticals Inc
Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells.EBI
Ligand Pharmaceuticals Inc
Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo.EBI
Ume£ University
Identification of a New RXR? Antagonist Targeting the Coregulator-Binding Site.EBI
Xiamen University
Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity.EBI
SRI International
Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties.EBI
Ligand Pharmaceuticals Inc
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.EBI
Ligand Pharmaceuticals Inc
Discovery of a small molecular compound simultaneously targeting RXR and HADC: design, synthesis, molecular docking and bioassay.EBI
Shenyang Pharmaceutical University
Structure-activity relationship study on benzoic acid part of diphenylamine-based retinoids.EBI
Tohoku Pharmaceutical University
Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity.EBI
SRI International
Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells.EBI
Ligand Pharmaceuticals Inc
Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids.EBI
Allergan Inc
Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity.EBI
University of Alabama at Birmingham
Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors.EBI
Allergan Inc
Sulfonyl-containing phenyl-pyrrolyl pentane analogues: Novel non-secosteroidal vitamin D receptor modulators with favorable physicochemical properties, pharmacokinetic properties and anti-tumor activity.EBI
China Pharmaceutical University
Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist.EBI
King's College
Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics.EBI
Swiss Federal Institute of Technology (ETH)
Indazole-based ligands for estrogen-related receptor ? as potential anti-diabetic agents.EBI
Janssen Research and Development LLC
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.EBI
St. John's University
The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells.BDB
Georgetown University
Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR.BDB
University of Texas Southwestern Medical Center
8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists.BDB
Bristol-Myers Squibb Co.
Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes.BDB
Universita degli Studi