BDBM64987 5-nitro-8-quinolinol::5-nitroquinolin-8-ol::8-HYDROXY-5-NITROQUINOLINE::MLS000069750::SMR000059036::cid_19910::nitroxoline

SMILES Oc1ccc([N+]([O-])=O)c2cccnc12

InChI Key InChIKey=RJIWZDNTCBHXAL-UHFFFAOYSA-N

Data  7 KI  8 IC50  2 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 64987   

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
E£Tv£S Lor£Nd University

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataKi:  3.95E+4nMAssay Description:Mixed inhibition of cathepsin B (unknown origin) endopeptidase activity assessed as inhibition constant for enzyme-substrate-inhibitor complexMore data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataKi:  3.95E+4nMAssay Description:Mixed inhibition of recombinant human cathepsin B endopeptidase activity assessed as inhibitory constant for enzyme-substrate-inhibitor complex using...More data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataKi:  1.54E+5nMAssay Description:Mixed inhibition of recombinant human cathepsin B endopeptidase activity assessed as inhibitory constant for enzyme-inhibitor complex using Z-Arg-Arg...More data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataKi:  1.54E+5nMAssay Description:Mixed inhibition of cathepsin B (unknown origin) endopeptidase activity assessed as inhibition constant for enzyme-inhibitor complexMore data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataKi:  2.72E+5nMAssay Description:Non-competitive inhibition of recombinant human cathepsin B exopeptidase activity assessed as inhibitory constant for enzyme-inhibitor complex using ...More data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataKi:  2.72E+5nMAssay Description:Noncompetitive inhibition of cathepsin B (unknown origin) exopeptidase activity assessed as inhibition constant for enzyme-inhibitor complexMore data for this Ligand-Target Pair
TargetCystathionine gamma-lyase(Homo sapiens (Human))
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataIC50:  1.07E+4nMAssay Description:Inhibition of human CSE using H-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystathionine gamma-lyase(Homo sapiens (Human))
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human CSE using H-Cys as the substrate by LC/MS/MS-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataIC50:  55nMAssay Description:Inhibition of recombinant human N-terminal His-tagged MetAP2 expressed in baculovirus infected BTI-TN-5B1-4 insect cells using Met-Pro-pNA as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataIC50:  980nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) using biotin labelled NeC: SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K as substrate preincubated for 15...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataIC50:  980nMAssay Description:Inhibition of BRD4 in human MV4-11 cells using biotin labelled N-C:SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K as substrate preincubated for 15...More data for this Ligand-Target Pair
TargetVacuolar aminopeptidase 1(Saccharomyces cerevisiae)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataEC50:  752nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetVacuolar aminopeptidase 1(Saccharomyces cerevisiae)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataEC50:  607nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCystathionine gamma-lyase(Homo sapiens (Human))
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of human methionine aminopeptidase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human methionine aminopeptidase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank