BindingDB BDBM78576 CIS-THIOTHIXENE::MLS000028463::SMR000058396::THIOTHIXENE::cid

BDBM78576 CIS-THIOTHIXENE::MLS000028463::SMR000058396::THIOTHIXENE::cid_941651::med.21724, Compound Thiothixene

SMILES CN(C)S(=O)(=O)c1ccc2Sc3ccccc3\C(=C\CCN3CCN(C)CC3)c2c1

InChI Key InChIKey=GFBKORZTTCHDGY-UHFFFAOYSA-N

Data 48 KI 2 IC50 4 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 54 hits for monomerid = 78576

Nuclear receptor subfamily 1 group I member 2(Human)
National Institutes of Health Chemical Genomics Center

Curated by ChEMBL

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

EC50: 7.10E+3nMAssay Description:Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysisMore data for this Ligand-Target Pair

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Date in BDB:
5/8/2016
Entry Details Article
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Nuclear receptor subfamily 1 group I member 2(Human)
National Institutes of Health Chemical Genomics Center

Curated by ChEMBL

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

EC50: 1.26E+4nMAssay Description:Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysisMore data for this Ligand-Target Pair

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Date in BDB:
5/8/2016
Entry Details Article
PubMed

Bile salt export pump(Human)
Astrazeneca

Curated by ChEMBL

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

IC50: 3.04E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair

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Date in BDB:
9/28/2019
Entry Details Article
PubMed

Ubiquitin-conjugating enzyme E2 N(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

IC50: 2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair

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Date in BDB:
8/2/2011
Entry Details
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Replicase polyprotein 1ab(SARS-CoV)
University of Bonn

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

EC50: 5.31E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair

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Date in BDB:
11/7/2020
Entry Details Article
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Orf1a protein(MERS-CoV)
University of Bonn

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

EC50: 9.29E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair

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Date in BDB:
11/7/2020
Entry Details Article
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D(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 0.120nMMore data for this Ligand-Target Pair

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Date in BDB:
3/3/2012
Entry Details Article
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D(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 0.450nMMore data for this Ligand-Target Pair

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Date in BDB:
11/26/2011
Entry Details Article
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D(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 0.450nMMore data for this Ligand-Target Pair

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Date in BDB:
11/23/2011
Entry Details Article
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D(2) dopamine receptor(Rat)
Case Western Reserve University

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 0.630nMMore data for this Ligand-Target Pair

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Date in BDB:
2/20/2012
Entry Details Article
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D(2) dopamine receptor(Rat)
Case Western Reserve University

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 0.630nMMore data for this Ligand-Target Pair

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Date in BDB:
12/29/2011
Entry Details
PubMed

D(2) dopamine receptor(Rat)
Case Western Reserve University

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 0.660nMMore data for this Ligand-Target Pair

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Date in BDB:
11/22/2011
Entry Details Article
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D(2) dopamine receptor(Bovine)
TBA

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 1.40nMMore data for this Ligand-Target Pair

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Date in BDB:
2/25/2012
Entry Details Article
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D(2) dopamine receptor(Bovine)
TBA

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 1.5nMMore data for this Ligand-Target Pair

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Date in BDB:
9/24/2011
Entry Details
PubMed

Histamine H1 receptor(Human)
Mayo Foundation

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 4.40nMMore data for this Ligand-Target Pair

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Date in BDB:
11/26/2011
Entry Details Article
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Histamine H1 receptor(Human)
Mayo Foundation

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 5.88nMMore data for this Ligand-Target Pair

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Date in BDB:
11/23/2011
Entry Details Article
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Histamine H1 receptor(Human)
Mayo Foundation

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 6nMMore data for this Ligand-Target Pair

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Date in BDB:
11/26/2011
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D(4) dopamine receptor(Human)
University of Toronto

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 6.40nMMore data for this Ligand-Target Pair

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Date in BDB:
3/3/2012
Entry Details Article
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Alpha-1A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 11.0nMMore data for this Ligand-Target Pair

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Date in BDB:
11/23/2011
Entry Details Article
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Alpha-1A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 11nMMore data for this Ligand-Target Pair

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Date in BDB:
11/26/2011
Entry Details Article
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5-hydroxytryptamine receptor 7(Rat)
Case Western Reserve University

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 12nMMore data for this Ligand-Target Pair

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Date in BDB:
12/29/2011
Entry Details
PubMed

Alpha-1A adrenergic receptor(Rat)
Janssen Pharmaceutica

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 25nMMore data for this Ligand-Target Pair

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Date in BDB:
12/26/2011
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Histamine H1 receptor(Rat)
TBA

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 27nMMore data for this Ligand-Target Pair

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Date in BDB:
9/24/2011
Entry Details Article
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5-hydroxytryptamine receptor 6(Rat)
Case Western Reserve University

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 45nMMore data for this Ligand-Target Pair

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Date in BDB:
12/29/2011
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5-hydroxytryptamine receptor 2A(Rat)
Case Western Reserve University

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 50nMMore data for this Ligand-Target Pair

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Date in BDB:
2/20/2012
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5-hydroxytryptamine receptor 2A(Rat)
Case Western Reserve University

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 50nMMore data for this Ligand-Target Pair

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Date in BDB:
11/9/2011
Entry Details
PubMed

5-hydroxytryptamine receptor 2A(Rat)
Case Western Reserve University

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 50.1nMMore data for this Ligand-Target Pair

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Date in BDB:
12/29/2011
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D(4) dopamine receptor(Rat)
Case Western Reserve University

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 77nMMore data for this Ligand-Target Pair

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Date in BDB:
2/20/2012
Entry Details Article
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5-hydroxytryptamine receptor 2C(Human)
Mayo Clinic

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 130nMMore data for this Ligand-Target Pair

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Date in BDB:
11/23/2011
Entry Details Article
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D(2) dopamine receptor(Bovine)
TBA

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 145nMMore data for this Ligand-Target Pair

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Date in BDB:
9/24/2011
Entry Details
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Alpha-2A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 200nMMore data for this Ligand-Target Pair

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Date in BDB:
11/26/2011
Entry Details Article
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Alpha-2A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 200nMMore data for this Ligand-Target Pair

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Date in BDB:
11/23/2011
Entry Details Article
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5-hydroxytryptamine receptor 6(Human)
University of Washington

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 320nMMore data for this Ligand-Target Pair

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Date in BDB:
2/20/2012
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D(4) dopamine receptor(Human)
University of Toronto

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 410nMMore data for this Ligand-Target Pair

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Date in BDB:
2/29/2012
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D(1A) dopamine receptor(Bovine)
TBA

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 540nMMore data for this Ligand-Target Pair

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Date in BDB:
2/25/2012
Entry Details Article
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D(1A) dopamine receptor(Bovine)
TBA

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 540nMMore data for this Ligand-Target Pair

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Date in BDB:
9/24/2011
Entry Details
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D(4) dopamine receptor(Human)
University of Toronto

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 685nMMore data for this Ligand-Target Pair

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Date in BDB:
2/29/2012
Entry Details
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Alpha-2C adrenergic receptor(Rat)
Janssen Pharmaceutica

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 1.20E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
12/26/2011
Entry Details Article
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5-hydroxytryptamine receptor 2C(Human)
Mayo Clinic

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 1.31E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
4/24/2012
Entry Details
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Alpha-2C adrenergic receptor(Rat)
Janssen Pharmaceutica

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 1.40E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
12/26/2011
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5-hydroxytryptamine receptor 1A/1B/1D/2C(Human)
Mayo Clinic

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 1.41E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
11/23/2011
Entry Details Article
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D(1A) dopamine receptor(Rat)
UniversitÉ

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 1.52E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
11/22/2011
Entry Details Article
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Muscarinic acetylcholine receptor M4(Human)
Mayo Clinic

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 1.54E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
11/9/2011
Entry Details
PubMed

5-hydroxytryptamine receptor 2C(Rat)
Stanford University

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 1.55E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
11/9/2011
Entry Details
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5-hydroxytryptamine receptor 2C(Rat)
Stanford University

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 1.58E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
12/29/2011
Entry Details
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Muscarinic acetylcholine receptor M3(Human)
Mayo Clinic

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 1.60E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
11/9/2011
Entry Details
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Muscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 2.10E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
11/9/2011
Entry Details
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Muscarinic acetylcholine receptor M1(Human)
Mayo Clinic

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 2.60E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
11/9/2011
Entry Details
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Muscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 2.90E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
11/26/2011
Entry Details Article
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Muscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP K_i Database

BDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)

Ki: 2.94E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
11/23/2011
Entry Details Article
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Displayed 1 to 50 (of 54 total ) | Next | Last >>

Filter my 54 hits

Targets 23▿
- D(2) dopamine receptor 9
- D(4) dopamine receptor 4
- Histamine H1 receptor 4
- 5-hydroxytryptamine receptor 2C 4
- D(1A) dopamine receptor 4
- Alpha-1A adrenergic receptor 3
- 5-hydroxytryptamine receptor 2A 3
- Muscarinic acetylcholine receptor M2 3
- Alpha-2C adrenergic receptor 2
- Nuclear receptor subfamily 1 group I member 2 2
- 5-hydroxytryptamine receptor 6 2
- Alpha-2A adrenergic receptor 2
- Beta-2 adrenergic receptor 2
- Orf1a protein 1
- Replicase polyprotein 1ab 1
- Muscarinic acetylcholine receptor M5 1
- Muscarinic acetylcholine receptor M4 1
- Muscarinic acetylcholine receptor M3 1
- 5-hydroxytryptamine receptor 7 1
- Muscarinic acetylcholine receptor M1 1
- 5-hydroxytryptamine receptor 1A/1B/1D/2C 1
- Bile salt export pump 1
- Ubiquitin-conjugating enzyme E2 N 1
Publications 21▿
- Ann N Y Acad Sci 537: 435-42 (1988) 7
- J Pharmacol Exp Ther 260: 576-80 (1992) 5
- J Pharmacol Exp Ther 268: 1403-10 (1994) 5
- Eur J Pharmacol 103: 197-204 (1984) 5
- Mol Pharmacol 12: 800-12 (1976) 4
- Psychopharmacology (Berl) 120: 365-8 (1995) 3
- Eur J Pharmacol 129: 49-55 (1986) 3
- Drug Metab Dispos 39: 151-9 (2010) 2
- Med Res Rev (2020) 2
- J Neuropsychiatry Clin Neurosci 8: 223-6 (1996) 2
- Mol Pharmacol 12: 568-80 (1976) 2
- Mol Psychiatry 3: 123-34 (1998) 2
- J Pharmacol Exp Ther 260: 1361-5 (1992) 2
- Life Sci 37: 1971-83 (1985) 2
- J Pharmacol Exp Ther 282: 1011-9 (1997) 2
- J Pharmacol Exp Ther 295: 226-32 (2000) 1
- Drug Metab Dispos 40: 2332-41 (2012) 1
- PubChem Bioassay (2011) 1
- Proc Natl Acad Sci U S A 75: 6290-4 (1978) 1
- J Neurochem 66: 47-56 (1996) 1
- Brain Res 304: 1-7 (1984) 1
Institutions 15▿
- Mayo Clinic 17
- TBA 9
- Case Western Reserve University 8
- Janssen Pharmaceutica 3
- Stanford University 2
- UniversitÉ 2
- University of Bonn 2
- Neurogen 2
- University of Toronto 2
- National Institutes of Health Chemical Genomics Center 2
- Astrazeneca 1
- Mayo Foundation 1
- Albany Medical College 1
- Burnham Center For Chemical Genomics 1
- University of Washington 1
Affinity: 0.12 to 3.0E+4 nM▿
- Ki 48
- IC50 2
- EC50 4
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1