BindingDB BDBM14390 5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::5-{2-ethoxy-5-[(4-methylpiperazine-1-)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::CHEMBL192::SILDENAFIL CITRATE::Sildenafil::Sildenafil#::US11155558, Compound sildenafil::US11242347, Compound sildenafil::US11897890, Compound sildenafil::US12139461, Compound sildenafil::Viagra

BDBM14390 5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::5-{2-ethoxy-5-[(4-methylpiperazine-1-)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::CHEMBL192::SILDENAFIL CITRATE::Sildenafil::Sildenafil#::US11155558, Compound sildenafil::US11242347, Compound sildenafil::US11897890, Compound sildenafil::US12139461, Compound sildenafil::Viagra

SMILES CCCc1c2c(n(n1)C)C(=O)NC(=N2)c3cc(ccc3OCC)S(=O)(=O)N4CCN(CC4)C

InChI Key InChIKey=BNRNXUUZRGQAQC-UHFFFAOYSA-N

Data 12 KI 185 IC50 3 EC50

PDB links: 5 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 200 hits for monomerid = 14390

cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 3.5nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair

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Date in BDB:
3/26/2007
Entry Details Article
PubMed PDB

3D Structure (crystal)

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma(Dog)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 33nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair

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Date in BDB:
3/26/2007
Entry Details Article
PubMed

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Plexxikon

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1.50E+3nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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Date in BDB:
4/9/2007
Entry Details Article
PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase [574-941](Human)
Plexxikon

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 3.50E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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Date in BDB:
4/9/2007
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cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084](Human)
Plexxikon

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1.50E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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Date in BDB:
4/9/2007
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B [316-320,321-700,S319G,N320S,N321H,T322M](Human)
Plexxikon

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 2.00E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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Date in BDB:
4/9/2007
Entry Details Article
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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M)(Human)
Plexxikon

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1.40E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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Date in BDB:
4/9/2007
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase [531-875](Human)
Plexxikon

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 2.20nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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Date in BDB:
4/9/2007
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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 7B [91-450](Human)
Plexxikon

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 7.80E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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Date in BDB:
4/9/2007
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Plexxikon

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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Date in BDB:
4/9/2007
Entry Details Article
PubMed

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593](Human)
Plexxikon

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 5.60E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
4/9/2007
Entry Details Article
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [432-779](Human)
Plexxikon

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 6.80E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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Date in BDB:
4/9/2007
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Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489](Human)
Plexxikon

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 6.10E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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Date in BDB:
4/9/2007
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PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase [535-860](Human)
University of North Carolina at Chapel Hill

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 2.40nMpH: 7.8 T: 2°CAssay Description:Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea...More data for this Ligand-Target Pair

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Date in BDB:
5/7/2007
Entry Details Article
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase [1-662,679-875](Human)
University of North Carolina at Chapel Hill

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 5.90nMpH: 7.8 T: 2°CAssay Description:Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea...More data for this Ligand-Target Pair

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Date in BDB:
5/7/2007
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase [1-660,682-875](Human)
University of North Carolina at Chapel Hill

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 188nMpH: 7.8 T: 2°CAssay Description:Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea...More data for this Ligand-Target Pair

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Date in BDB:
5/7/2007
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3D Structure (crystal)

Phosphodiesterase(Trypanosoma cruzi)
University of North Carolina

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1.00E+3nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair

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Date in BDB:
8/8/2012
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cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 3nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair

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Date in BDB:
8/8/2012
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PubMed PDB

3D Structure (crystal)

Replicase polyprotein 1ab(SARS-CoV)
Michigan State University

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1.25E+4nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair

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Date in BDB:
1/27/2022
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Replicase polyprotein 1ab(2019-nCoV)
Michigan State University

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 8.25E+3nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair

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Date in BDB:
1/27/2022
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cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1.00E+3nMAssay Description:The inhibition of recombinant human (rh) PDE5A by test compounds is measured in a radiometric assay based on Scintillation Proximity Assay (SPA) tech...More data for this Ligand-Target Pair

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Date in BDB:
3/13/2022
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Go to US Patent
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 5.40nMAssay Description:Experimental protocol: The test compound, i.e the compound of the present invention, reference compound or water (control) are added to a buffer cont...More data for this Ligand-Target Pair

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Date in BDB:
4/18/2024
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 5.40nMAssay Description:TBDMore data for this Ligand-Target Pair

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Date in BDB:
6/10/2022
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 39.4nMAssay Description:Phosphodiesterase type 5 (PDE5) inhibition assay of compounds of formula I, III, and IV and the reference drug sildenafil were performed according to...More data for this Ligand-Target Pair

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Date in BDB:
3/18/2025
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3D Structure (crystal)

Bile salt export pump(Human)
Astrazeneca

Curated by ChEMBL

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1.64E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair

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Date in BDB:
9/28/2019
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PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1.26E+4nMAssay Description:Inhibition of human PDE5A preincubated for 30 mins followed by TMB substrate addition by spectrophotometryMore data for this Ligand-Target Pair

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Date in BDB:
3/18/2020
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 2.20nMAssay Description:Inhibition of recombinant human full length PDE5A1 catalytic domain expressed in Escherichia coli BL21 using [3H]cGMP as substrate after 15 mins by l...More data for this Ligand-Target Pair

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Date in BDB:
8/16/2020
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 4nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair

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Date in BDB:
8/16/2020
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 3.70nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE5A1 catalytic domain expressed in Baculovirus infected Sf9 insect cells using FA...More data for this Ligand-Target Pair

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Date in BDB:
8/16/2020
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 8.5nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair

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Date in BDB:
8/16/2020
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 5.10nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liqu...More data for this Ligand-Target Pair

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Date in BDB:
8/16/2020
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Rat)
Kasetsart University

Curated by ChEMBL

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 2nMAssay Description:Inhibition of rat lung PDE5 using [3H]cGMP as substrate measured after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair

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Date in BDB:
2/22/2021
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3D Structure (crystal)

cGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Chinese Academy of Sciences

Curated by ChEMBL

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1.00E+4nMAssay Description:Inhibition of human PDE2A1 expressed in baculovirus infected sf9 cells using [3H]cAMP as substrate measured after 30 mins by scintillation proximity ...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Human)
Chinese Academy of Sciences

Curated by ChEMBL

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 819nMAssay Description:Inhibition of N-terminal GST-tagged human PDE1 expressed in baculovirus infected sf9 cells using [3H]cAMP as substrate measured after 30 mins by scin...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
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cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Chinese Academy of Sciences

Curated by ChEMBL

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged human PDE3 expressed in baculovirus infected sf9 cells using [3H]cAMP as substrate measured after 30 mins by scin...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
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cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Chinese Academy of Sciences

Curated by ChEMBL

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged human PDE4 expressed in baculovirus infected sf9 cells using [3H]cAMP as substrate measured after 30 mins by scin...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
Entry Details Article
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3D Structure (crystal)

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B(Human)
Chinese Academy of Sciences

Curated by ChEMBL

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged human PDE7 expressed in baculovirus infected sf9 cells using [3H]cAMP as substrate measured after 30 mins by scin...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
Entry Details Article
PubMed

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Plexxikon

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged full length human PDE8A1 expressed in baculovirus infected sf9 cells using [3H]cAMP as substrate measured after 3...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
Entry Details Article
PubMed

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Chinese Academy of Sciences

Curated by ChEMBL

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged full length human PDE9A2 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 3...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
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Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Human)
Chinese Academy of Sciences

Curated by ChEMBL

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 36nMAssay Description:Inhibition of N-terminal GST-tagged human PDE6C expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sci...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
Entry Details Article
PubMed

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Chinese Academy of Sciences

Curated by ChEMBL

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 4.93E+3nMAssay Description:Inhibition of N-terminal GST-tagged human PDE11A4 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by s...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
Entry Details Article
PubMed

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Chinese Academy of Sciences

Curated by ChEMBL

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged human PDE10A expressed in baculovirus infected sf9 cells using [3H]cAMP as substrate measured after 30 mins by sc...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
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cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 4.30nMAssay Description:Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
University of Strasbourg

Curated by ChEMBL

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 3.30E+3nMAssay Description:Inhibition of bovine aortic smooth muscle PDE5 using cGMP as substrate incubated for 30 mins in presence of EGTA and [3H]cGMP by liquid scintillation...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1nMAssay Description:Inhibition of human platelets PDE5More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 1.60nMAssay Description:Inhibition of phosphodiesterase type 5 (PDE5) of human plateletsMore data for this Ligand-Target Pair

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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 2.00E+4nMAssay Description:Inhibition of human His-tagged PDE4B catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair

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Date in BDB:
2/27/2021
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 2.20nMAssay Description:Inhibition of recombinant human PDE5A1 catalytic domain (535 to 860 residues) expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate...More data for this Ligand-Target Pair

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Date in BDB:
2/27/2021
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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 2.20nMAssay Description:Inhibition of human PDE5AMore data for this Ligand-Target Pair

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Date in BDB:
2/27/2021
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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL

PNG

BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)

IC50: 2.00E+4nMAssay Description:Inhibition of human His-tagged PDE4B catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair

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Date in BDB:
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3D Structure (crystal)

Displayed 1 to 50 (of 200 total ) | Next | Last >>

Filter my 200 hits

Targets 50▿
- cGMP-specific 3',5'-cyclic phosphodiesterase 82
- cGMP-dependent 3',5'-cyclic phosphodiesterase 10
- Potassium voltage-gated channel subfamily H member 2 10
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B 8
- cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D 6
- P04972/P11541/P16586/P22571/P23439/Q95142 5
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 5
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B 5
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 4
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 4
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 4
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C 4
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 4
- O43924/P16499/P18545/P35913/P51160/Q13956 3
- Phosphodiesterase 3
- Potassium voltage-gated channel subfamily E/KQT member 1 2
- ATP-binding cassette sub-family C member 5 2
- Replicase polyprotein 1ab 2
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase 2
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B 2
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'/cGMP-specific 3',5'-cyclic phosphodiesterase 2
- Sodium channel protein type 5 subunit alpha 2
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 2
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M) 1
- cGMP-specific 3',5'-cyclic phosphodiesterase [531-875] 1
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [432-779] 1
- Indoleamine 2,3-dioxygenase 1 1
- Indoleamine 2,3-dioxygenase 2 1
- Potassium voltage-gated channel subfamily D member 3 1
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 1
- cGMP-dependent 3',5'-cyclic phosphodiesterase [574-941] 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B [316-320,321-700,S319G,N320S,N321H,T322M] 1
- Voltage-dependent L-type calcium channel subunit alpha-1C 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 7B [91-450] 1
- cGMP-specific 3',5'-cyclic phosphodiesterase [1-662,679-875] 1
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084] 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D 1
- cGMP-specific 3',5'-cyclic phosphodiesterase [1-660,682-875] 1
- ATP-binding cassette sub-family C member 4 1
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 1
- cGMP-specific 3',5'-cyclic phosphodiesterase [535-860] 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4A 1
- Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489] 1
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593] 1
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B 1
- Bile salt export pump 1
- Adenosine receptor A2a 1
- ...
Publications 50▿
- Bioorg Med Chem 23: 2121-8 (2015) 12
- J Med Chem 62: 4979-4990 (2019) 11
- Structure 12: 2233-47 (2004) 11
- J Med Chem 59: 7029-65 (2016) 10
- J Pharmacol Toxicol Methods 70: 246-54 (2014) 9
- J Med Chem 55: 10540-50 (2012) 7
- J Med Chem 46: 4533-42 (2003) 6
- J Med Chem 44: 2204-18 (2001) 6
- Bioorg Med Chem Lett 13: 2341-5 (2003) 6
- Bioorg Med Chem Lett 14: 2955-8 (2004) 5
- Bioorg Med Chem Lett 15: 2365-9 (2005) 5
- Bioorg Med Chem Lett 14: 2099-103 (2004) 4
- Bioorg Med Chem Lett 12: 865-8 (2002) 4
- Bioorg Med Chem Lett 6: 1819-1824 (1996) 4
- J Med Chem 64: 4462-4477 (2021) 3
- J Biol Chem 281: 21469-79 (2006) 3
- J Med Chem 46: 4525-32 (2003) 3
- Bioorg Med Chem Lett 15: 2790-4 (2005) 3
- J Med Chem 48: 3449-62 (2005) 3
- Bioorg Med Chem Lett 15: 1829-33 (2005) 2
- J Nat Prod 71: 1513-7 (2008) 2
- Mol Pharmacol 63: 1094-103 (2003) 2
- J Med Chem 49: 5363-71 (2006) 2
- Bioorg Med Chem Lett 22: 7641-6 (2012) 2
- Bioorg Med Chem Lett 15: 2381-4 (2005) 2
- Bioorg Med Chem Lett 15: 3900-7 (2005) 2
- J Med Chem 59: 8967-9004 (2016) 2
- Bioorg Med Chem Lett 18: 6279-82 (2008) 2
- J Med Chem 49: 3581-94 (2006) 2
- Bioorg Med Chem Lett 20: 383-6 (2010) 2
- J Biol Chem 287: 11788-97 (2012) 2
- J Med Chem 44: 1025-7 (2001) 2
- Eur J Med Chem 60: 285-94 (2013) 2
- J Med Chem 64: 16922-16955 (2021) 2
- Eur J Med Chem 177: 269-290 (2019) 2
- Eur J Med Chem 232: (2022) 1
- Bioorg Med Chem Lett 24: 5175-80 (2014) 1
- Bioorg Med Chem 16: 7599-606 (2008) 1
- J Med Chem 55: 5311-25 (2012) 1
- Bioorg Med Chem 76: (2022) 1
- Bioorg Med Chem Lett 13: 761-5 (2003) 1
- Bioorg Med Chem Lett 14: 1577-80 (2004) 1
- Bioorg Med Chem Lett 29: 267-270 (2019) 1
- Bioorg Med Chem Lett 20: 3125-8 (2010) 1
- Bioorg Med Chem Lett 92: (2023) 1
- RSC Med Chem 13: 1300-1321 (2022) 1
- J Med Chem 45: 3844-53 (2002) 1
- Bioorg Med Chem Lett 22: 3983-7 (2012) 1
- J Med Chem 51: 2807-15 (2008) 1
- Eur J Med Chem 150: 506-524 (2018) 1
- ...
Institutions 39▿
- Chinese Academy of Sciences 21
- Tanabe Seiyaku 12
- Csir-Indian Institute of Integrative Medicine 12
- Plexxikon 11
- Bristol-Myers Squibb Pharmaceutical Research Institute 10
- Vrije Universiteit Amsterdam 10
- Glaxosmithkline 9
- University of Oxford 9
- Schering-Plough Research Institute 5
- TBA 4
- Ewha Womans University 4
- Bayer 4
- Chong Kun Dang Research Institute 4
- University of Navarra 3
- Columbia University 3
- Pfizer 3
- German University In Cairo 3
- Monash University (Parkville Campus) 3
- University of North Carolina at Chapel Hill 3
- The University of Sydney 2
- University of Milan 2
- RhôNe-Poulenc Rorer 2
- University of North Carolina 2
- Università 2
- Michigan State University 2
- The Netherlands Cancer Institute 2
- Bayer Healthcare 2
- University of Strasbourg 2
- Tianjin University 1
- King Mongkut'S Institute of Technology 1
- Mitsubishi Tanabe Pharma 1
- Universidade Federal De Lavras-Ufla 1
- Kasetsart University 1
- Johnson & Johnson Pharmaceutical Research & Development 1
- Shaoxing University 1
- Radboud University Nijmegen Medical Centre 1
- University of Bologna 1
- State University of Campinas 1
- Youai 1
- ...
Affinity: 0.30 to 1.3E+6 nM▿
- Ki 12
- IC50 185
- EC50 3
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1