BDBM307525 (S)-3-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxybenzyl)(2,2-difluoroethyl)amino)propanoic acid::US10150743, Example 6::US10562861, Ex. No. 6

SMILES CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(CN(CCC(O)=O)CC(F)F)cc1OC

InChI Key InChIKey=ZSLUPNMTHNULTB-IBGZPJMESA-N

Data  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307525   

TargetToll-like receptor 7(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307525((S)-3-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6...)
Affinity DataEC50:  6.60E+3nMAssay Description:Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 8(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307525((S)-3-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6...)
Affinity DataEC50: <1.00E+4nMAssay Description:TLR8/NF-kB/SEAPorter HEK 293 Cell Line (Imgenex Corporation) is a stably co-transfected cell line which expresses full-length human TLR8 and the secr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent