BDBM385100 US10287267, Compound 1014::US10287267, Compound 118::US10287267, Compound 965::US10508099, Compound 1014::US10556885, Compound 1014::US11174244, Compound 1014::US11673881, Compound 965

SMILES CN1CCN(CC(=O)Nc2cc3cc(ccc3cn2)-c2cnn(C)c2)CC1

InChI Key InChIKey=LXBSEOHXKNBKIJ-UHFFFAOYSA-N

Data  36 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 385100   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Biosplice Therapeutics

US Patent
LigandPNGBDBM385100(US10287267, Compound 1014 | US10287267, Compound 1...)
Affinity DataEC50:  9.60nMAssay Description:Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Biosplice Therapeutics

US Patent
LigandPNGBDBM385100(US10287267, Compound 1014 | US10287267, Compound 1...)
Affinity DataEC50:  96nMAssay Description:The GSK3B kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divisio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Biosplice Therapeutics

US Patent
LigandPNGBDBM385100(US10287267, Compound 1014 | US10287267, Compound 1...)
Affinity DataEC50:  10.6nMAssay Description:Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Biosplice Therapeutics

US Patent
LigandPNGBDBM385100(US10287267, Compound 1014 | US10287267, Compound 1...)
Affinity DataEC50:  9.40nMAssay Description:Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Biosplice Therapeutics

US Patent
LigandPNGBDBM385100(US10287267, Compound 1014 | US10287267, Compound 1...)
Affinity DataEC50:  79nMAssay Description:The GSK3B kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divisio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Biosplice Therapeutics

US Patent
LigandPNGBDBM385100(US10287267, Compound 1014 | US10287267, Compound 1...)
Affinity DataEC50:  79nMAssay Description:The GSK3B kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divisio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent