BindingDB BDBM31096 CHEMBL290084::Staurosporine::cid

BDBM31096 CHEMBL290084::Staurosporine::cid_451705

SMILES CN[C@H]1C[C@@H]2O[C@](C)([C@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13

InChI Key InChIKey=HKSZLNNOFSGOKW-HMWZOHBLSA-N

Data 18 KI 2 IC50 265 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 31096

Tyrosine-protein kinase Blk(Homo sapiens (Human))
East China University of Science and Technology

US Patent

BDBM31096(CHEMBL290084 | Staurosporine | cid_451705)

IC50: 5.60nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid Patents Similars

Details US Patent

Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science and Technology

US Patent

BDBM31096(CHEMBL290084 | Staurosporine | cid_451705)

IC50: 0.280nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid Patents Similars

Details US Patent

Filter my 285 hits

Targets 260▿
- Epidermal growth factor receptor 8
- Mast/stem cell growth factor receptor Kit 5
- Tyrosine-protein kinase ABL1 5
- Receptor-type tyrosine-protein kinase FLT3 3
- Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] 2
- Ribosomal protein S6 kinase alpha-1 2
- Ephrin type-A receptor 7 2
- Tyrosine-protein kinase Blk 2
- Ribosomal protein S6 kinase alpha-6 2
- Ribosomal protein S6 kinase alpha-4 2
- Fibroblast growth factor receptor 3 2
- Ribosomal protein S6 kinase alpha-5 2
- Tyrosine-protein kinase Tec 1
- BMP-2-inducible protein kinase 1
- LIM domain kinase 1 1
- Discoidin domain-containing receptor 2 [A642S] 1
- ALK tyrosine kinase receptor 1
- NUAK family SNF1-like kinase 2 1
- Non-receptor tyrosine-protein kinase TYK2 1
- Glycogen synthase kinase-3 beta 1
- Calcium/calmodulin-dependent protein kinase type 1 1
- NUAK family SNF1-like kinase 1 1
- AP2-associated protein kinase 1 1
- Calcium/calmodulin-dependent protein kinase type II subunit beta 1
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 1
- P2Y purinoceptor 14 1
- Serine/threonine-protein kinase PAK 1 1
- Protein kinase C theta type 1
- Serine/threonine-protein kinase PAK 2 1
- Serine/threonine-protein kinase PAK 3 1
- Dual specificity mitogen-activated protein kinase kinase 2 1
- Serine/threonine-protein kinase PAK 4 1
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 1
- Serine/threonine-protein kinase tousled-like 2 1
- Dual specificity mitogen-activated protein kinase kinase 3 1
- Serine/threonine-protein kinase PAK 5 1
- Serine/threonine-protein kinase PAK 6 1
- Serine/threonine-protein kinase tousled-like 1 1
- Tyrosine-protein kinase JAK3 1
- Tyrosine-protein kinase JAK2 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- Epidermal growth factor receptor [1-999,L858R] 1
- Dual specificity mitogen-activated protein kinase kinase 6 1
- Dual specificity mitogen-activated protein kinase kinase 4 1
- Tyrosine-protein kinase ZAP-70 1
- Casein kinase I isoform gamma-2 1
- Casein kinase I isoform epsilon 1
- Myosin light chain kinase 3 1
- Ephrin type-A receptor 1 1
- Ephrin type-A receptor 2 1
- Ephrin type-A receptor 5 1
- Tyrosine-protein kinase BTK 1
- Ephrin type-A receptor 4 1
- Tyrosine-protein kinase receptor UFO 1
- Insulin-like growth factor 1 receptor 1
- Activin receptor type-1 1
- Myosin light chain kinase 2, skeletal/cardiac muscle 1
- Tyrosine-protein kinase Srms 1
- Wee1-like protein kinase 1
- Ankyrin repeat and protein kinase domain-containing protein 1 1
- Tyrosine-protein kinase Lyn 1
- Focal adhesion kinase 1 1
- Cyclin-dependent kinase 2 1
- Tyrosine-protein kinase TXK 1
- Ephrin type-A receptor 8 1
- Tyrosine-protein kinase ABL1 [1-999,Q252H] 1
- Death-associated protein kinase 2 1
- Death-associated protein kinase 1 1
- Serine/threonine-protein kinase D2 1
- Serine/threonine-protein kinase D3 1
- Isoform 3 of Ribosomal protein S6 kinase alpha-2 (3) 1
- Serine/threonine-protein kinase D1 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 1
- Death-associated protein kinase 3 1
- Cyclin-dependent kinase 9 1
- Serine/threonine-protein kinase pim-3 1
- Cyclin-dependent kinase 8 1
- Cyclin-dependent kinase 7 1
- Serine/threonine-protein kinase pim-1 1
- Cyclin-dependent kinase 5 1
- Serine/threonine-protein kinase pim-2 1
- Cyclin-dependent kinase 3 1
- Serine/threonine-protein kinase 36 1
- Cyclin-dependent kinase 16 1
- Testis-specific serine/threonine-protein kinase 1 1
- Protein kinase C epsilon type 1
- Cyclin-dependent kinase 17 1
- Cyclin-dependent kinase 19 1
- Protein-tyrosine kinase 6 1
- Casein kinase II subunit alpha 1
- Cyclin-dependent kinase 14 1
- Cytoplasmic tyrosine-protein kinase BMX 1
- Tyrosine-protein kinase ABL2 1
- Tyrosine-protein kinase ABL1 [T315I] 1
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 1
- cGMP-dependent protein kinase 2 1
- cGMP-dependent protein kinase 1 1
- Serine/threonine-protein kinase SIK2 1
- Tyrosine-protein kinase Fes/Fps 1
- Serine/threonine-protein kinase SIK1 1
- 3-phosphoinositide-dependent protein kinase 1 1
- Mitogen-activated protein kinase 1 1
- Serine/threonine-protein kinase 3 1
- Mitogen-activated protein kinase 3 1
- Serine/threonine-protein kinase 4 1
- SRSF protein kinase 2 1
- Mitogen-activated protein kinase 7 1
- Receptor-type tyrosine-protein kinase FLT3 [D835H] 1
- Calcium/calmodulin-dependent protein kinase type IV 1
- Mitogen-activated protein kinase 8 1
- Tyrosine-protein kinase SYK 1
- Serine/threonine-protein kinase RIO1 1
- Serine/threonine-protein kinase LATS1 1
- Serine/threonine-protein kinase RIO3 1
- Serine/threonine-protein kinase 32B 1
- Vascular endothelial growth factor receptor 2 1
- Insulin receptor 1
- Tyrosine-protein kinase HCK 1
- Receptor-type tyrosine-protein kinase FLT3 [D835Y] 1
- Vascular endothelial growth factor receptor 3 1
- Vascular endothelial growth factor receptor 1 1
- Serine/threonine-protein kinase PLK1 1
- Serine/threonine-protein kinase PLK3 1
- Serine/threonine-protein kinase PLK4 1
- Tyrosine-protein kinase receptor TYRO3 1
- Serine/threonine-protein kinase BRSK1 1
- cAMP-dependent protein kinase catalytic subunit alpha 1
- Citron Rho-interacting kinase 1
- Platelet-derived growth factor receptor alpha 1
- Serine/threonine-protein kinase BRSK2 1
- Dual specificity protein kinase CLK1 [R432A] 1
- Serine/threonine-protein kinase Chk1 1
- cAMP-dependent protein kinase catalytic subunit PRKX 1
- SRSF protein kinase 1 1
- Tyrosine-protein kinase Yes 1
- Serine/threonine-protein kinase MRCK beta 1
- Serine/threonine-protein kinase MRCK gamma 1
- Casein kinase II subunit alpha' 1
- Serine/threonine-protein kinase STK11 1
- Cyclin-G-associated kinase 1
- Receptor tyrosine-protein kinase erbB-4 1
- Tyrosine-protein kinase FRK 1
- Hepatocyte growth factor receptor 1
- Serine/threonine-protein kinase Nek9 1
- Serine/threonine-protein kinase Nek7 1
- Glycogen synthase kinase-3 alpha 1
- Serine/threonine-protein kinase Nek5 1
- Serine/threonine-protein kinase Nek2 1
- Serine/threonine-protein kinase Nek1 1
- MAP/microtubule affinity-regulating kinase 3 1
- MAP kinase-interacting serine/threonine-protein kinase 2 1
- MAP kinase-interacting serine/threonine-protein kinase 1 1
- MAP/microtubule affinity-regulating kinase 4 1
- Serine/threonine-protein kinase 38-like 1
- Dual specificity protein kinase TTK 1
- Myosin-IIIb 1
- Myosin-IIIa 1
- Tyrosine-protein kinase ITK/TSK 1
- Myotonin-protein kinase 1
- Protein kinase C eta type 1
- Bone morphogenetic protein receptor type-1A 1
- Serine/threonine-protein kinase 16 1
- Receptor-interacting serine/threonine-protein kinase 2 1
- Non-receptor tyrosine-protein kinase TNK1 1
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 1
- Serine/threonine-protein kinase NLK 1
- Casein kinase I isoform delta 1
- Cyclin-dependent kinase 18 [3-474] 1
- Serine/threonine-protein kinase 26 1
- Serine/threonine-protein kinase 24 1
- Serine/threonine-protein kinase 25 1
- Dual specificity testis-specific protein kinase 1 1
- Receptor-type tyrosine-protein kinase FLT3 [N841I] 1
- Serine/threonine-protein kinase 33 1
- Ephrin type-B receptor 1 1
- Ephrin type-B receptor 2 1
- Activated CDC42 kinase 1 1
- MAP kinase-activated protein kinase 2 1
- Platelet-derived growth factor receptor beta 1
- Epithelial discoidin domain-containing receptor 1 1
- Muscle, skeletal receptor tyrosine-protein kinase 1
- Tyrosine-protein kinase Fer 1
- Tyrosine-protein kinase receptor Tie-1 1
- 5'-AMP-activated protein kinase catalytic subunit alpha-2 1
- Calcium/calmodulin-dependent protein kinase type II subunit delta 1
- Proto-oncogene tyrosine-protein kinase ROS 1
- Serine/threonine-protein kinase DCLK1 1
- Calcium/calmodulin-dependent protein kinase kinase 1 1
- Serine/threonine-protein kinase DCLK2 1
- Calcium/calmodulin-dependent protein kinase kinase 2 1
- Serine/threonine-protein kinase DCLK3 1
- Serine/threonine-protein kinase TNNI3K 1
- Interferon-induced, double-stranded RNA-activated protein kinase 1
- Angiopoietin-1 receptor 1
- Mitogen-activated protein kinase kinase kinase kinase 3 1
- Mitogen-activated protein kinase kinase kinase kinase 1 1
- Serine/threonine-protein kinase MRCK alpha 1
- Casein kinase I isoform alpha-like 1
- Mitogen-activated protein kinase kinase kinase kinase 4 1
- Mitogen-activated protein kinase kinase kinase kinase 5 1
- Mitogen-activated protein kinase 15 1
- Mitogen-activated protein kinase 14 1
- 5'-AMP-activated protein kinase catalytic subunit alpha-1 1
- Activin receptor type-1B 1
- Myosin light chain kinase family member 4 1
- Mitogen-activated protein kinase kinase kinase 9 1
- RAC-gamma serine/threonine-protein kinase 1
- Mitogen-activated protein kinase kinase kinase 5 1
- Interleukin-1 receptor-associated kinase 3 1
- Mitogen-activated protein kinase kinase kinase 4 1
- RAC-alpha serine/threonine-protein kinase 1
- Proto-oncogene tyrosine-protein kinase Src 1
- Activin receptor type-2B 1
- Myosin light chain kinase, smooth muscle 1
- BDNF/NT-3 growth factors receptor 1
- Serine/threonine-protein kinase 17A 1
- Tyrosine-protein kinase Lck 1
- Serine/threonine-protein kinase 17B 1
- Protein kinase C delta type 1
- NT-3 growth factor receptor 1
- Dual specificity protein kinase CLK4 1
- Dual specificity protein kinase CLK3 1
- Dual specificity protein kinase CLK2 1
- High affinity nerve growth factor receptor 1
- Protein-tyrosine kinase 2-beta 1
- Tyrosine-protein kinase Mer 1
- Serine/threonine-protein kinase N2 1
- cAMP-dependent protein kinase catalytic subunit beta 1
- Calcium/calmodulin-dependent protein kinase type II subunit gamma 1
- Serine/threonine-protein kinase N1 1
- Ribosomal protein S6 kinase alpha-2 1
- Ribosomal protein S6 kinase alpha-3 1
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1
- Calcium/calmodulin-dependent protein kinase type 1D 1
- STE20-like serine/threonine-protein kinase 1
- Calcium/calmodulin-dependent protein kinase type 1G 1
- Fibroblast growth factor receptor 4 1
- Tyrosine-protein kinase Fgr 1
- Aurora kinase B 1
- Aurora kinase A 1
- Fibroblast growth factor receptor 1 1
- Fibroblast growth factor receptor 2 1
- Aurora kinase C 1
- Mitogen-activated protein kinase 12 1
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 1
- RAC-beta serine/threonine-protein kinase 1
- Mitogen-activated protein kinase 10 1
- Tyrosine-protein kinase Fyn 1
- Tyrosine-protein kinase CSK 1
- Macrophage colony-stimulating factor 1 receptor 1
- eIF-2-alpha kinase GCN2 1
- Maternal embryonic leucine zipper kinase 1
- Serine/threonine-protein kinase MARK1 1
- Serine/threonine-protein kinase MARK2 1
- Epidermal growth factor receptor [G719C] 1
- TRAF2 and NCK-interacting protein kinase 1
- Mitogen-activated protein kinase kinase kinase 12 1
- Mitogen-activated protein kinase kinase kinase 10 1
- Mitogen-activated protein kinase kinase kinase 11 1
- Ephrin type-A receptor 3 [1-975] 1
Publications 50▿
- PubChem Bioassay (2008) 34
- US Patent US9670213 (2017) 2
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- ...
Institutions 2▿
- Ambit Biosciences 82
- East China University of Science and Technology 2
- ...
Affinity: 0.020 to 8.4E+6 nM▿
- Ki 18
- IC50 2
- Kd 265
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 1
Catalog Cmpds: 1