BDBM14433 4-[2-(4-{6,15-dibromo-13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-yl}piperidin-1-yl)-2-oxoethyl]piperidine-1-carboxamide::4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide::Lonafarnib::SCH-66336::Sarasar::racemic mixture
SMILES NC(=O)N1CCC(CC(=O)N2CCC(CC2)C2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
InChI Key InChIKey=DHMTURDWPRKSOA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 14433
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Abbott Laboratories
Abbott Laboratories
Affinity DataIC50: 8.30nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Abbott Laboratories
Abbott Laboratories
Affinity DataIC50: >1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair