BDBM322158 2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)phenoxy)-N-isopropylacetamide TFA salt::US10183931, Example 48::US10696660, Example 48::US11311541, Example 48::US9815820, 48

SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)N1CCN(C)CC1

InChI Key InChIKey=NYHFQHJERQSETO-UHFFFAOYSA-N

Data  8 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 322158   

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM322158(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Affinity DataKi:  10nMAssay Description:Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM322158(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Affinity DataKi:  20nMAssay Description:Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM322158(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Affinity DataIC50:  470nMAssay Description:Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM322158(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Affinity DataIC50:  330nMAssay Description:Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent