BDBM127657 US10251889, Example 30::US10758542, Example 30::US8791123, 30::US9782415, Example 30::US9796724, Example 30

SMILES NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F

InChI Key InChIKey=JBTQGTQNCVBRNY-CQSZACIVSA-N

Data  32 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 127657   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Array Biopharm

US Patent
LigandPNGBDBM127657(US10251889, Example 30 | US10758542, Example 30 | ...)
Affinity DataIC50:  1.95nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Array Biopharm

US Patent
LigandPNGBDBM127657(US10251889, Example 30 | US10758542, Example 30 | ...)
Affinity DataIC50: >1.00E+3nMAssay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Array Biopharm

US Patent
LigandPNGBDBM127657(US10251889, Example 30 | US10758542, Example 30 | ...)
Affinity DataIC50:  1.90nMAssay Description:Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Array Biopharm

US Patent
LigandPNGBDBM127657(US10251889, Example 30 | US10758542, Example 30 | ...)
Affinity DataIC50: >1.00E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak1 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Array Biopharm

US Patent
LigandPNGBDBM127657(US10251889, Example 30 | US10758542, Example 30 | ...)
Affinity DataIC50: >1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Array Biopharm

US Patent
LigandPNGBDBM127657(US10251889, Example 30 | US10758542, Example 30 | ...)
Affinity DataIC50: >1.00E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak3 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Array Biopharm

US Patent
LigandPNGBDBM127657(US10251889, Example 30 | US10758542, Example 30 | ...)
Affinity DataIC50: >1.00E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In DepthDetails US Patent