BDBM50357312 IBRUTINIB::PCI-32765::US10124003, Ref. Ex. Compound 1::US10711006, Compound Ibrutinib::US10793575, Example ibrutinib::US10835536, Ref. Ex. Comp 1::US10919899, Ibrutinib::US11078206, Example Ibrutinib::US11186578, Example Ibrutinib::US11339167, Example Ibrutinib::US11407754, Example Ibrutinib::US20230364079, Example Ibrutinib::US20240059694, Compound Ibrutinib::US20240139326, Compound Ibrutinib::US9108973, Ref 1::US9181263, 1::US9278100, 1
SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C
InChI Key InChIKey=XYFPWWZEPKGCCK-GOSISDBHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50357312
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataKi: 1.10E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human full length BTK using FITC-AHA-EEPLYWSFPAKKK-NH2 as substrate after 90 mins by microfluid mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of BTK in whole blood (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in anti-IgM-induced CD69 expression incubated for 1 hr by flow cytometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of BTK in human PBMCMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of BTK in human WBCMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human PBMC assessed as suppression of BCR-induced CD69 expression on B cells pretreated f...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged BTK (2 to 659 residues) expressed in baculovirus expression system using FITC-AHA-E...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of BTK in human whole bloodMore data for this Ligand-Target Pair