BDBM50012434 (REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hexan-1-ol::1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hexan-1-ol::1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hexan-1-ol (RG 5901)::1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hexan-1-ol(REV-5901)::CHEMBL8747::REV-5901::REV-901

SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1

InChI Key InChIKey=JRLOEMCOOZSCQP-UHFFFAOYSA-N

Data  3 KI  15 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50012434   

TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50012434((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of [3H]-LTD4 binding to LTD4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50012434((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...)
Affinity DataKi:  8.00E+3nMAssay Description:Compound was tested for the inhibition of [3H]-leukotriene D4 binding to LTD4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50012434((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...)
Affinity DataIC50:  300nMAssay Description:Ability to inhibit Lipoxygenase in vitro was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50012434((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...)
Affinity DataIC50: >4.50E+4nMAssay Description:Compound was tested for its in vitro inhibitory activity against RBL-1 5-LO (insuluble above 45 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50012434((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...)
Affinity DataIC50: >4.50E+4nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase from rat basophilic leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50012434((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...)
Affinity DataIC50:  300nMAssay Description:Inhibition of rat polymorphonuclear leukocyte (PMN) 5-Lipoxygenase in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50012434((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...)
Affinity DataIC50:  150nMAssay Description:Inhibition of 5-Lipoxygenase (5-LO) in rat basophilic leukemic cellsMore data for this Ligand-Target Pair
In DepthDetails Article