BDBM309529 3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione::US10945994, Compound 1::US9603836, Compound 1::US9603836, Compound 1a::US9949951, 1a

SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1

InChI Key

Data  42 IC50  3 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 309529   

TargetTryptophan 2,3-dioxygenase(Human)
Bryn Mawr College

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  3.78E+5nMAssay Description:Inhibition of human TDO expressed in human T-REx cells using L-tryptophan as substrate after 20 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Bryn Mawr College

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  210nMAssay Description:Inhibition of IDO1 in human HeLa cells using L-tryptophan as substrate after 20 hrsMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 2(Mouse)
Bryn Mawr College

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  3.27E+5nMAssay Description:Inhibition of mouse IDO2 expressed in human T-REx cells using L-tryptophan as substrate after 20 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed