BDBM50530399 CHEMBL4476830
SMILES CNC(=O)c1cnc(Nc2ccc(F)cn2)cc1Nc1ccc(F)c(F)c1OC
InChI Key InChIKey=YJELMXAGNJWBFO-UHFFFAOYSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50530399
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK2(Human)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of [3H]cAMP binding to recombinant human His-Tb fused PDE4D2 (86 to 413 residues) expressed in Escherichia coli using [3H]cAMP as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of [3H]cAMP binding to recombinant human His-Tb fused PDE4D2 (86 to 413 residues) expressed in Escherichia coli using [3H]cAMP as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of TYK2 JH2 domain in human whole blood assessed as inhibition of IFNalpha-induced STAT5 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK2(Human)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Human)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of TYK2 JH2 domain in human whole blood assessed as inhibition of IFNalpha-induced STAT5 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Human)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair