BDBM50212258 GS-4997::Selonsertib

SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1

InChI Key InChIKey=YIDDLAAKOYYGJG-UHFFFAOYSA-N

Data  15 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50212258   

TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50212258(GS-4997 | Selonsertib)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of ASK1 in human HEK293 cells transfected with AP1 assessed as inhibition of AP1-induced firefly luciferase activity preincubated for 1 hr...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50212258(GS-4997 | Selonsertib)
Affinity DataIC50:  13nMAssay Description:Inhibition of human full length recombinant ASK1 using STK-Substrate-3 biotin as substrate in presence of ATP measured after 2 hrs by HTRP kinase ass...More data for this Ligand-Target Pair