BDBM4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US20240058459, Compound Sunit-inib::US9163010, Sunitinib::US9914707, SU11248
SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
InChI Key InChIKey=WINHZLLDWRZWRT-ATVHPVEESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 79 hits for monomerid = 4814
Affinity DataKd: 210nMAssay Description:Average Binding Constant for ABL1(T315I) ; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 180nMAssay Description:Average Binding Constant for INSR; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 6.00E+3nMAssay Description:Average Binding Constant for PRKACA; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 5.80E+3nMAssay Description:Average Binding Constant for CAMKK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 3.30E+3nMAssay Description:Average Binding Constant for MAP3K4; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 35nMAssay Description:Average Binding Constant for FLT4; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 370nMAssay Description:Average Binding Constant for CAMK2A; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit beta(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 3.20E+3nMAssay Description:Average Binding Constant for CAMK2B; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 2.00E+3nMAssay Description:Average Binding Constant for EPHA6; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 21nMAssay Description:Average Binding Constant for STK17A; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 130nMAssay Description:Average Binding Constant for AAK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 530nMAssay Description:Average Binding Constant for ABL1(M351T) ; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 1.00E+3nMAssay Description:Average Binding Constant for ABL1 ; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 720nMAssay Description:Average Binding Constant for ABL1(Y253F); NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 2.30E+3nMAssay Description:Average Binding Constant for ABL1(Q252H) ; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 500nMAssay Description:Average Binding Constant for NEK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 220nMAssay Description:Average Binding Constant for STK17B; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 310nMAssay Description:Average Binding Constant for Aurora3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:Average Binding Constant for GAK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 0.210nMAssay Description:Average Binding Constant for PDGFRB; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 2.00E+3nMAssay Description:Average Binding Constant for CAMK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 57nMAssay Description:Average Binding Constant for MYLK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 1.20E+3nMAssay Description:Average Binding Constant for LCK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Average Binding Constant for ULK3 m; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 220nMAssay Description:Average Binding Constant for NTRK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 990nMAssay Description:Average Binding Constant for CAMK1G; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 0.230nMAssay Description:Average Binding Constant for VEGFR2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 230nMAssay Description:Average Binding Constant for TTK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 9.20nMAssay Description:Average Binding Constant for JAK1 (Kin.Dom. 1); NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 300nMAssay Description:Average Binding Constant for FGFR3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 160nMAssay Description:Average Binding Constant for STK3_m; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 2.20E+3nMAssay Description:Average Binding Constant for ACK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 55nMAssay Description:Average Binding Constant for RPS6KA3 (Kin.Dom. 1); NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 540nMAssay Description:Average Binding Constant for LYN; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 300nMAssay Description:Average Binding Constant for DAPK3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 470nMAssay Description:Average Binding Constant for DAPK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
TargetPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 70nMAssay Description:Average Binding Constant for PHkg1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 360nMAssay Description:Average Binding Constant for STK16; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 530nMAssay Description:Average Binding Constant for FGFR2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 870nMAssay Description:Average Binding Constant for ABL1(H396P) ; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 240nMAssay Description:Average Binding Constant for YES; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 52nMAssay Description:Average Binding Constant for PRKAA1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 1.10E+3nMAssay Description:Average Binding Constant for CAMK1D; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 320nMAssay Description:Average Binding Constant for MARK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 3.90E+3nMAssay Description:Average Binding Constant for FYN; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 380nMAssay Description:Average Binding Constant for STK18; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 290nMAssay Description:Average Binding Constant for FGR; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 5(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 77nMAssay Description:Average Binding Constant for MAP4K5; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 710nMAssay Description:Average Binding Constant for EPHA7; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 640nMAssay Description:Average Binding Constant for STK10; NA=Not Active at 10 uMMore data for this Ligand-Target Pair