BDBM50358430 CHEMBL1614725

SMILES CC(C)(O)CC(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(c4)C(F)(F)F)c(Cl)c3)c12

InChI Key InChIKey=ZYQXEVJIFYIBHZ-UHFFFAOYSA-N

Data  39 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 50358430   

TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of N-terminus flag-tagged LynB expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  260nMAssay Description:Inhibition of N-terminus peptide (DYKDDDD)-tagged HER4 expressed in baculovirus infected insect cells using [gamma-32P]ATP as substrate after 60 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of C-terminus flag-tagged MEK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of N-terminus flag-tagged MEK5 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  17nMAssay Description:Inhibition of human N-terminus peptide (DYKDDDD)-tagged HER2 expressed in baculovirus infected insect cells using [gamma-32P]ATP as substrate after 6...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of N-terminus flag-tagged c-MET expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged VEGRF1 expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged VEGRF2 expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged FGFR1 expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged FGFR3 expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged PDGFRalpha expressed in baculovirus infected insect cells using ATP as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged PDGFRbeta expressed in baculovirus infected insect cells using ATP as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged TIE2 expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged c-kit expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged IGF-1R expressed in baculovirus infected insect cells using ATP as substrate after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged Src expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of N-terminus flag-tagged Lck expressed in baculovirus infected insect cells using ATP as substrate after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of N-terminus flag-tagged CSK expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged FAK expressed in baculovirus infected insect cells using ATP as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged LynA expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged ASK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group C member 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged TAK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-terminus flag-tagged MEKK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintilla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-terminus flag-tagged IKK-beta expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scinti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged JNK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged ERK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged p38alpha expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scinti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged PKCtheta expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scinti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged GSK3-beta expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged B-raf expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintilla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged TTK expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged PLK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of N-terminus 6XHis-tagged Aurora-B expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed