BDBM4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US20240058459, Compound Sunit-inib::US9163010, Sunitinib::US9914707, SU11248
SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
InChI Key InChIKey=WINHZLLDWRZWRT-ATVHPVEESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 317 hits for monomerid = 4814
Affinity DataKd: 4.30nMAssay Description:Binding constant for FLT3(D835H) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 830nMAssay Description:Binding constant for ABL1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.70E+3nMAssay Description:Binding constant for RPS6KA5(Kin.Dom.2 - N-terminal) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 96nMAssay Description:Binding constant for RPS6KA4(Kin.Dom.1 - C-terminal) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(L747-S752del, P753S) kinase domainMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(E545K) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 380nMAssay Description:Binding constant for PRKD2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 940nMAssay Description:Binding constant for IRAK3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(L861Q) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(G719S) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(L858R) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.990nMAssay Description:Binding constant for FLT3(ITD) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(E746-A750del) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.00E+3nMAssay Description:Binding constant for ABL1(H396P) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(L747-T751del,Sins) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 2.80E+3nMAssay Description:Binding constant for ABL1(E255K) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 100nMAssay Description:Binding constant for full-length DLKMore data for this Ligand-Target Pair
Affinity DataKd: 12nMAssay Description:Binding constant for RET kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.280nMAssay Description:Binding constant for KIT(V559D,T670I) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.410nMAssay Description:Binding constant for KIT(V559D) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 300nMAssay Description:Binding constant for CHEK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 290nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for DMPK kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 950nMAssay Description:Binding constant for ABL1(Y253F) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.370nMAssay Description:Binding constant for KIT kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PRKCH kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 2.30nMAssay Description:Binding constant for FLT3(D835Y) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 140nMAssay Description:Binding constant for ABL1(T315I) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 890nMAssay Description:Binding constant for ABL1(Q252H) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for BRAF kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 2.40E+3nMAssay Description:Binding constant for RPS6KA6(Kin.Dom.1 - C-terminal) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 140nMAssay Description:Binding constant for RPS6KA1(Kin.Dom.1 - N-terminal) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 380nMAssay Description:Binding constant for KIT(D816V) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 380nMAssay Description:Binding constant for AURKB kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PRKG1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 6.80E+3nMAssay Description:Binding constant for EGFR(G719C) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 17nMAssay Description:Binding constant for RPS6KA2(Kin.Dom.1 - N-terminal) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(L747-E749del, A750P) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 2.40nMAssay Description:Binding constant for FLT3(N841I) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 530nMAssay Description:Binding constant for FRK kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Binding constant for AAK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length BTKMore data for this Ligand-Target Pair
Affinity DataKd: 190nMAssay Description:Binding constant for PLK4 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 2.00E+3nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for DDR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 580nMAssay Description:Binding constant for full-length SNF1LK2More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 19nMAssay Description:Binding constant for AMPK-alpha1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length CDK9More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 89nMAssay Description:Binding constant for AMPK-alpha2 kinase domainMore data for this Ligand-Target Pair