BDBM3534 6,7-dimethoxy-N-[3-(trifluoromethyl)phenyl]quinazolin-4-amine::CHEMBL316064::PD153035 Analog 34

SMILES COc1cc2ncnc(Nc3cccc(c3)C(F)(F)F)c2cc1OC

InChI Key InChIKey=KEQCEKUDWPXRRQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 3534   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM3534(6,7-dimethoxy-N-[3-(trifluoromethyl)phenyl]quinazo...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation treated 30 mins before Hoechst 33342 addition measured up to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM3534(6,7-dimethoxy-N-[3-(trifluoromethyl)phenyl]quinazo...)
Affinity DataIC50:  1.98E+3nMAssay Description:Inhibition of human BCRP expressed in MDCK2 cells assessed as pheophorbide A accumulation treated 30 mins before pheophorbide A addition measured up ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed