BDBM50062641 5-((R)-1-Azetidin-2-ylmethoxy)-2-chloro-pyridine::CHEMBL430497::TEBENICILINE::Tebanicline tosylate
SMILES Clc1ccc(OC[C@H]2CCN2)cn1
InChI Key InChIKey=MKTAGSRKQIGEBH-SSDOTTSWSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50062641
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataKi: 0.0400nMAssay Description:Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 in rat brain using [3H]-cytisine as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.0480nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataKi: 0.0550nMAssay Description:Compound was evaluated for its ability to displace [3H]cytisine from K177 cells expressing human Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataKi: 0.0550nMAssay Description:Compound was evaluated for its ability to displace [125I]alpha-bungarotoxin (alpha-BgT) from K28 cells expressing human Nicotinic acetylcholine recep...More data for this Ligand-Target Pair
Affinity DataKi: 2.06E+3nMAssay Description:Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes.More data for this Ligand-Target Pair
Affinity DataKi: 2.06E+3nMAssay Description:Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtypeMore data for this Ligand-Target Pair
TargetAcetylcholine receptor subunit alpha(Pacific electric ray)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataKi: 1.00E+4nMAssay Description:Binding affinity against Nicotinic Acetylcholine Receptor was determined by measuring the displacement of [3H]-cytisine from a preparation of whole r...More data for this Ligand-Target Pair
TargetAcetylcholine receptor subunit alpha(Pacific electric ray)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataKi: 1.00E+4nMAssay Description:Compound was evaluated for its ability to displace [125 I]alpha-bungarotoxin (alpha-BgT) from torpedo alpha1-beta1-gamma1 electroplaxMore data for this Ligand-Target Pair
Affinity DataEC50: 200nMAssay Description:Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtypeMore data for this Ligand-Target Pair
Affinity DataEC50: 190nMAssay Description:Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 200nMAssay Description:Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from whole rat brain Nicotinic acetylcholine receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 5.60E+4nMAssay Description:Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes.More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.10E+4nMAssay Description:Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes.More data for this Ligand-Target Pair