BDBM246861 3-[1-(6- chloropyridin-2- yl)pyrrolidin-3-yl]-3- [4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]propanenitrile::US10005788, 2 (2nd peak, cis-)::US10053465, 3::US10065963, Compound 3::US10125150, Example 3::US10336759, # 3::US10479803, Example 3::US10519163, Example 3::US10675284, Example 3::US11084822, Example 3::US11130767, # 3::US11136326, Example 3::US11304949, Compound 6::US11324749, Comp. No. 6::US11406640, Comp. No. 6::US11596632, Comp. No. 6::US20240058343, Compound 6::US9732097, Example 3

SMILES Clc1cccc(n1)N1CCC(C1)C(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12

InChI Key

Data  36 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 246861   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246861(3-[1-(6- chloropyridin-2- yl)pyrrolidin-3-yl]-3- [...)
Affinity DataIC50: <10nMAssay Description:PI3K: The kinase reactions are conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors are ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246861(3-[1-(6- chloropyridin-2- yl)pyrrolidin-3-yl]-3- [...)
Affinity DataIC50: <10nMAssay Description:PI3Kδ:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent