BDBM246861 3-[1-(6- chloropyridin-2- yl)pyrrolidin-3-yl]-3- [4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]propanenitrile::US10005788, 2 (2nd peak, cis-)::US10053465, 3::US10065963, Compound 3::US10125150, Example 3::US10336759, # 3::US10479803, Example 3::US10519163, Example 3::US10675284, Example 3::US11084822, Example 3::US11130767, # 3::US11136326, Example 3::US11304949, Compound 6::US11324749, Comp. No. 6::US11406640, Comp. No. 6::US11596632, Comp. No. 6::US20240058343, Compound 6::US9732097, Example 3
SMILES Clc1cccc(n1)N1CCC(C1)C(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
InChI Key
Data 36 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 246861
Affinity DataIC50: <10nMAssay Description:PI3K: The kinase reactions are conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors are ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: <10nMAssay Description:PI3Kδ:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL...More data for this Ligand-Target Pair