BDBM475736 8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2,2-difluoro-8-azaspiro[4.5]decan-1-amine::US10851110, Example 65A::US11466017, Example 65A

SMILES N[C@@H]1C(F)(F)CCC12CCN(c1cnc3c(-c4cccc(Cl)c4Cl)n[nH]c3n1)CC2

InChI Key InChIKey=LNKXXCNDICLLOS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 475736   

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 475736BDBM475736(8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...)
Affinity DataIC50: 235nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent