BDBM340095 (S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)imidazo[1,5- a]pyrazin-1-yl)-N-(thiazol-2- yl)benzamide::US10239883, Example 60::US10934296, Example 60::US9758524, Example 60

SMILES CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2nccs2)c2c(N)nccn12

InChI Key InChIKey=YBAJJYNSAQRPKE-KRWDZBQOSA-N

Data  16 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 340095   

TargetTyrosine-protein kinase Lck(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340095((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...)
Affinity DataEC50:  550nMAssay Description:Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340095((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...)
Affinity DataEC50: >1.00E+3nMAssay Description:Src enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Src enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase Fyn(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340095((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...)
Affinity DataEC50: >1.00E+3nMAssay Description:FynT enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.FynT enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase Lyn(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340095((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...)
Affinity DataEC50:  550nMAssay Description:Lyn enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lyn enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340095((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...)
Affinity DataEC50:  55nMAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Btk enzyme (H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent