BindingDB BDBM50001775 (ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-2,3-dihydro-1H-indolizin-5-one::(ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one::6-(2-(4-(bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one::6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-8,8a-dihydro-thiazolo[3,2-a]pyrimidin-5-one::6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one::6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one (Ritanserin)::6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one(Ritanserin)::CHEMBL267777::RITANSERIN::Ritanserine::cid_5074

BDBM50001775 (ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-2,3-dihydro-1H-indolizin-5-one::(ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one::6-(2-(4-(bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one::6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-8,8a-dihydro-thiazolo[3,2-a]pyrimidin-5-one::6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one::6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one (Ritanserin)::6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one(Ritanserin)::CHEMBL267777::RITANSERIN::Ritanserine::cid_5074

SMILES [#6]-c1nc2sccn2c(=O)c1-[#6]-[#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6](\c1ccc(F)cc1)-c1ccc(F)cc1

InChI Key InChIKey=JUQLTPCYUFPYKE-UHFFFAOYSA-N

Data 107 KI 26 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50001775

5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Syntex Discovery Research

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 0.0100nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Syntex Discovery Research

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 0.0830nM ΔG°: -12.8kcal/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Syntex Discovery Research

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 0.25nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Roche Bioscience

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 0.290nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Roche Bioscience

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 0.310nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Syntex Discovery Research

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 0.450nMAssay Description:Binding affinity to 5-HT2A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Syntex Discovery Research

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 0.450nMAssay Description:Binding affinity to 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Syntex Discovery Research

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 0.450nMAssay Description:Binding affinity to 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Roche Bioscience

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 0.540nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Roche Bioscience

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 0.631nMAssay Description:Binding affinity was evaluated in vitro by displacement of [3H]ketanserin from 5-hydroxytryptamine 2A receptor on rat cortical membraneMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Syntex Discovery Research

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 1nMMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Syntex Discovery Research

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 1.09nMMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Roche Bioscience

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 1.70nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopyMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Roche Bioscience

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 3.80nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Syntex Discovery Research

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 4.57nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Roche Bioscience

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 4.70nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Roche Bioscience

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 5.5nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Roche Bioscience

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 36nMAssay Description:Displacement of [3H]MDL100907 from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopyMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Roche Bioscience

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

Ki: 58.1nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Roche Bioscience

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

IC50: 1.70nMAssay Description:In vitro binding affinity towards serotonin 5-HT2A receptor in rat cortical membranes using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Roche Bioscience

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

IC50: 0.400nMAssay Description:Binding affinity to serotonin 5-hydroxytryptamine 2A receptors using a radioligand [3H]-ketanserin binding assay in rat cortical membranesMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Syntex Discovery Research

Curated by PDSP K_i Database

PNG

BDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)

IC50: 0.0690nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair

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Filter my 133 hits

Targets 22▿
- 5-hydroxytryptamine receptor 2A 22
- 5-hydroxytryptamine receptor 7 21
- 5-hydroxytryptamine receptor 2C 19
- 5-hydroxytryptamine receptor 2B 15
- D(2) dopamine receptor 13
- 5-hydroxytryptamine receptor 6 9
- Serotonin 2 (5-HT2) receptor 8
- Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor 5
- Alpha-1A adrenergic receptor 4
- 5-hydroxytryptamine receptor 1A 3
- Diacylglycerol kinase alpha 2
- 5-hydroxytryptamine receptor 1B 2
- 5-hydroxytryptamine receptor 1A/1B/1D/1F 1
- Alpha-2C adrenergic receptor 1
- D(4) dopamine receptor 1
- D(3) dopamine receptor 1
- 5-hydroxytryptamine receptor 2A/2B/2C 1
- Histamine H1 receptor 1
- D(1A) dopamine receptor 1
- 5-hydroxytryptamine receptor 3A 1
- Ubiquitin-conjugating enzyme E2 N 1
- 5-hydroxytryptamine receptor 1D 1
- ...
Publications 48▿
- Neuropharmacology 33: 275-317 (1994) 10
- J Med Chem 34: 2477-83 (1991) 8
- NIDA Res Monogr 178: 440-66 (1998) 7
- Br J Pharmacol 115: 622-8 (1995) 7
- Eur J Med Chem 164: 378-390 (2019) 6
- Br J Pharmacol 130: 692-8 (2000) 5
- Neuropharmacology 36: 621-9 (1997) 5
- J Pharmacol Exp Ther 317: 910-8 (2006) 5
- Trends Pharmacol Sci 18: 104-7 (1997) 4
- J Med Chem 35: 552-8 (1992) 4
- J Med Chem 39: 3723-38 (1996) 3
- Proc Natl Acad Sci U S A 83: 8784-8 (1986) 3
- Naunyn Schmiedebergs Arch Pharmacol 370: 114-23 (2004) 3
- J Med Chem 36: 2761-70 (1993) 3
- Mol Psychiatry 3: 123-34 (1998) 3
- Naunyn Schmiedebergs Arch Pharmacol 356: 328-34 (1997) 3
- J Med Chem 31: 2247-56 (1989) 3
- J Med Chem 35: 4813-22 (1993) 3
- J Med Chem 35: 4823-31 (1993) 3
- J Med Chem 46: 2795-812 (2003) 2
- J Pharmacol Exp Ther 276: 720-7 (1996) 2
- Br J Pharmacol 126: 179-88 (1999) 2
- Neuron 11: 449-58 (1993) 2
- Naunyn Schmiedebergs Arch Pharmacol 357: 17-24 (1998) 2
- J Pharmacol Exp Ther 260: 1361-5 (1992) 2
- J Med Chem 36: 3073-6 (1993) 2
- Bioorg Med Chem 16: 4661-9 (2008) 2
- J Med Chem 36: 1488-95 (1993) 2
- Naunyn Schmiedebergs Arch Pharmacol 365: 242-52 (2002) 2
- J Biol Chem 268: 18200-4 (1993) 2
- Neuropharmacology 36: 713-20 (1997) 2
- Br J Pharmacol 115: 107-16 (1995) 2
- J Med Chem 65: 10755-10808 (2022) 2
- J Biol Chem 268: 23422-6 (1993) 2
- Mol Pharmacol 43: 320-7 (1993) 2
- Psychopharmacology (Berl) 124: 57-73 (1996) 1
- J Pharmacol Exp Ther 262: 759-68 (1992) 1
- Bioorg Med Chem Lett 4: 415-420 (1994) 1
- PubChem Bioassay (2011) 1
- J Nat Prod 85: 2149-2158 (2022) 1
- Bioorg Med Chem Lett 26: 3216-3219 (2016) 1
- J Med Chem 46: 5638-50 (2003) 1
- J Med Chem 40: 586-93 (1997) 1
- Bioorg Med Chem Lett 10: 1097-100 (2000) 1
- J Med Chem 37: 950-62 (1994) 1
- J Pharmacol Exp Ther 247: 169-73 (1988) 1
- Br J Pharmacol 127: 1075-82 (1999) 1
- J Neurochem 66: 47-56 (1996) 1
Institutions 35▿
- H. Lundbeck 16
- University of Alberta 10
- Roche Bioscience 10
- Syntex Discovery Research 9
- Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer 8
- Sri International 7
- University of Piemonte Orientale 6
- Friedrich-Schiller-University Jena 5
- Acadia Pharmaceuticals 5
- National Institute of Neurological Disorders and Stroke 4
- Eli Lilly 4
- Scios Nova 4
- R. W. Johnson Pharmaceutical Research Institute 4
- The Oregon Health Sciences University 3
- RhôNe-Poulenc Rorer 3
- Vernalis Research 3
- University of Toronto 3
- Stanford University 2
- Beijing Normal University 2
- Monash University 2
- F. Hoffmann-La Roche 2
- The Scripps Research Institute 2
- Purdue University 2
- Virginia Commonwealth University 2
- Institut De Recherches Servier 2
- Synaptic Pharmaceutical 2
- Universidad Complutense 2
- City University Of New York 2
- TBA 1
- Burnham Center For Chemical Genomics 1
- University of Washington 1
- Faes 1
- Sanofi Recherche 1
- Vanderbilt University 1
- Janssen Research Foundation 1
Affinity: 0.010 to 2.0E+4 nM▿
- Ki 107
- IC50 26
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1