BDBM4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US20240058459, Compound Sunit-inib::US9163010, Sunitinib::US9914707, SU11248
SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
InChI Key InChIKey=WINHZLLDWRZWRT-ATVHPVEESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 4814
Affinity DataKd: 11nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 130nMAssay Description:Average Binding Constant for AAK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Binding affinity to AAK1More data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Binding constant for AAK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Binding constant for AAK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Binding affinity to wild type DNA-tagged human AAK1 (G25 to L333 residues) expressed in bacterial expression system by quantitative PCR based KINOMEs...More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Displacement of tracer 222 from GST-tagged recombinant human AAK1 catalytic domain (1 to 510 amino acids) expressed in insect cells shaken for 30 sec...More data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of AAK1 kinase in HEK-293 cellsMore data for this Ligand-Target Pair
Affinity DataKd: 35nMAssay Description:Binding affinity to AAK1 in HEK-293 cellsMore data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Binding affinity to AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair