BDBM50560766 CHEMBL4765062

SMILES Cc1cc(Nc2ccc(cc2)[N+]([O-])=O)nc(n1)-c1ccccc1

InChI Key InChIKey=WYLAKENCXDLFIA-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50560766   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-University Bonn

Curated by ChEMBL
LigandPNGBDBM50560766(CHEMBL4765062)
Affinity DataIC50:  52nMAssay Description:Inhibition of human ABCG2 expressed in MDCK2 cells co-expressing GFP preincubated for 30 mins followed by Hoechst 33342 addition and measured every 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-University Bonn

Curated by ChEMBL
LigandPNGBDBM50560766(CHEMBL4765062)
Affinity DataIC50:  156nMAssay Description:Inhibition of human ABCG2 expressed in MDCK2 cells co-expressing GFP preincubated for 15 mins followed by pheophorbideA addition and measured after 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-University Bonn

Curated by ChEMBL
LigandPNGBDBM50560766(CHEMBL4765062)
Affinity DataEC50:  16nMAssay Description:Inhibition of human ABCG2-mediated multidrug resistance in MDCK2 cells assessed as potentiation of SN-38-induced cytotoxicity by measuring half maxim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed