BDBM50047262 (R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile::4-(5,6,7,8-Tetrahydro-imidazo[1,5-a]pyridin-5-yl)-benzonitrile::CHEMBL287677::R-fadrozole
SMILES N#Cc1ccc(cc1)[C@H]1CCCc2cncn12
InChI Key InChIKey=CLPFFLWZZBQMAO-CQSZACIVSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50047262
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human CYP11B2 expressed in V79 cells using 11-deoxycorticosteron as substrate preincubated for 1 hr followed by substrate addition and ...More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human CYP11B2 expressed in chinese hamster V79 cellsMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Rattus norvegicus)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 118nMAssay Description:Inhibition of rat recombinant CYP11B2 using 11-deoxycorticosterone as substrate by cell-based assayMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate by cell-based assayMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP11B2 in human NCI-H295R cells assessed as inhibition of angiotensin-2-induced aldosterone production after 24 hrs by RIAMore data for this Ligand-Target Pair
Affinity DataIC50: 2.07E+3nMAssay Description:Concentration required to inhibit the activity of Angiotensin I converting enzyme by 50%More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human CYP11B2 expressed in HEK293A cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition meas...More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human aldosterone synthase expressed in V79 MZ cells pretreated with compound for 1 hr followed by addition of 500 nM 11-deoxycorticost...More data for this Ligand-Target Pair