BDBM33396 2,4-diaminofuro[2,3-d]pyrimidine, 2::E/Z ratio=2:1

SMILES CCC\C(=C\c1coc2nc(N)nc(N)c12)c1ccccc1OC

InChI Key InChIKey=QRIUQJQGVYRORZ-LUAWRHEFSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 33396   

TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

LigandPNGBDBM33396(2,4-diaminofuro[2,3-d]pyrimidine, 2 | E/Z ratio=2:...)
Affinity DataIC50:  3.70E+4nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM33396(2,4-diaminofuro[2,3-d]pyrimidine, 2 | E/Z ratio=2:...)
Affinity DataIC50:  1.22E+4nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

LigandPNGBDBM33396(2,4-diaminofuro[2,3-d]pyrimidine, 2 | E/Z ratio=2:...)
Affinity DataIC50:  1.52E+4nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Duquesne University

LigandPNGBDBM33396(2,4-diaminofuro[2,3-d]pyrimidine, 2 | E/Z ratio=2:...)
Affinity DataIC50:  7.92E+3nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed