BDBM50214615 CHEBI:64177::Clobenpropit

SMILES Clc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1

InChI Key InChIKey=UCAIEVHKDLMIFL-UHFFFAOYSA-N

Data  18 KI  3 IC50  4 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50214615   

TargetHistamine H4 receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50214615(CHEBI:64177 | Clobenpropit)
Affinity DataKi:  40nMAssay Description:Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50214615(CHEBI:64177 | Clobenpropit)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50214615(CHEBI:64177 | Clobenpropit)
Affinity DataKi:  50nMAssay Description:Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50214615(CHEBI:64177 | Clobenpropit)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50214615(CHEBI:64177 | Clobenpropit)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50214615(CHEBI:64177 | Clobenpropit)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50214615(CHEBI:64177 | Clobenpropit)
Affinity DataKi:  78nMAssay Description:Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50214615(CHEBI:64177 | Clobenpropit)
Affinity DataKi:  123nMAssay Description:Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50214615(CHEBI:64177 | Clobenpropit)
Affinity DataKi:  158nMAssay Description:Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50214615(CHEBI:64177 | Clobenpropit)
Affinity DataEC50:  851nMAssay Description:Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50214615(CHEBI:64177 | Clobenpropit)
Affinity DataKd:  31nMAssay Description:Binding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substra...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50214615(CHEBI:64177 | Clobenpropit)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human H4R by [35S]-GTPgammaS-binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50214615(CHEBI:64177 | Clobenpropit)
Affinity DataKd:  31nMAssay Description:Binding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substra...More data for this Ligand-Target Pair
In DepthDetails PubMed