BDBM19422 4-(acetylamino)-N-(2-amino-phenyl) benzamide::CI-994::N-(2-aminophenyl)-4-acetamidobenzamide::N-acetyldinaline::US11207431, Example F::US11377423, CI-994
SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1ccccc1N
InChI Key InChIKey=VAZAPHZUAVEOMC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 19422
Affinity DataKi: 37nM ΔG°: -10.1kcal/mole IC50: 41nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant HDAC1 (1 to 482 residues) expressed in Baculovirus using Ac-Leu-Gly-Lys(Ac)-AMC as substrate after 3 hrs by fluoresce...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human recombinant HDAC1 (1 to 482 residues) expressed in Baculovirus using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of human recombinant full length HDAC1 using fluorogenic substrate 3 after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of HDAC1 (unknown origin) by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of human recombinant His-tagged HDAC1 (482 residues) expressed in baculovirus infected insect cells using FLUOR DE LYS SIRT1 as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of recombinant human His tagged HDAC1 expressed in baculovirus infected insect cells assessed as decrease in deacetylation of FLUOR DE LYS...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant human full length C-terminal His/FALG-tagged HDAC1 expressed in Sf9 insect cells using FAM-labeled acetylated peptide A as ...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant human C-terminal His/FLAG-tagged HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using Boc-Lys(epsilon-Ac)-AMC as s...More data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:The following non-trypsin coupled in-vitro HDAC enzymatic endpoint assay was used to assay the compounds of the invention. Below is a standardized pr...More data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:The following non-trypsin coupled in-vitro HDAC enzymatic endpoint assay was used to assay the compounds of the invention. Below is a standardized pr...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Affinity DataIC50: 960nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair