BDBM50194756 CHEMBL3961701

SMILES CNCCN1CCC(CC1)OCc1ccccc1

InChI Key InChIKey=HBOJWAYLSJLULG-UHFFFAOYSA-N

Data  2 KI  10 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50194756   

TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50:  34nMAssay Description:Inhibition of human full length PRMT4 (1 to 608 residues) expressed in 293F cells assessed as inhibition of methylation activity preincubated with pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of PRMT4 in HEK293 cells assessed as reduction in Med12-Rme2a level measured after 72 hrs by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50:  32nMAssay Description:Inhibition of PRMT4 (unknown origin) using histone H3 (21 to 44 residues) as substrate measured after 60 mins in presence of SAM by AlphaLisa assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50:  34nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataKd:  100nMAssay Description:Binding affinity to human PRMT4 in presence of SAH by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed