BDBM50527406 CHEMBL4588333::US10981911, Example 45

SMILES Fc1ccc(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)cc1

InChI Key InChIKey=MMAFBZVPAFVVFX-RUCARUNLSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50527406   

TargetJAK3/JAK1(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50527406(CHEMBL4588333 | US10981911, Example 45)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC assessed as reduction in IL2-induced STAT5 phosphorylation pre-incubated for 30 mins before IL2 stimulation for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed