BDBM50002184 CHEMBL415330::H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-NH2::Linear Dyn A-(1-13)NH2::Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys(Dynorphin A)::Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-NH2
SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
InChI Key InChIKey=YJLKYUMEUZAMMP-IWIISZHXSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50002184
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Oregon State University
Curated by ChEMBL
Oregon State University
Curated by ChEMBL
Affinity DataKi: 0.0230nMAssay Description:Inhibition of [3H]- bremazocine to opioid receptor kappa of guinea pig cerebral membranes was determinedMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Oregon State University
Curated by ChEMBL
Oregon State University
Curated by ChEMBL
Affinity DataKi: 0.150nMAssay Description:Compound was tested for binding affinity towards kappa opioid receptor in guinea pig cerebellar membrane using [3H]-bremazocineMore data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Affinity DataKi: 0.390nMAssay Description:Binding affinity towards Opioid receptor kappa 1 expressed in CHO cells was determined by using [3H]-diprenorphine as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO-K1 cells incubated for 1 hr by 1450 microbeta scintillation counter anal...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Oregon State University
Curated by ChEMBL
Oregon State University
Curated by ChEMBL
Affinity DataIC50: 0.114nMAssay Description:Binding affinity against Opioid receptor kappa 1 in guinea pig brain homogenate using [3H]- U-69593 as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 2.80nMAssay Description:Agonist activity at mouse KOR expressed in HEK293 cell assessed as inhibition of cAMP concentration incubated for 1 hrs by time-resolved fluorescence...More data for this Ligand-Target Pair
Affinity DataEC50: 116nMAssay Description:Agonist activity at EGFP-tagged mouse KOR expressed in HEK293 cells co-expressing beta-arrestin2 nano-luciferase assessed as beta-arrestin2 recruitme...More data for this Ligand-Target Pair