BDBM195608 CPI-455::US20240139197, Compound 3

SMILES CC(C)c1c([nH]c2c(cnn2c1=O)C#N)-c1ccccc1

InChI Key InChIKey=DHXKRMSKXLDZGY-UHFFFAOYSA-N

Data  41 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 195608   

TargetLysine-specific demethylase 3B(Human)
Genentech

LigandPNGBDBM195608(CPI-455 | US20240139197, Compound 3)
Affinity DataIC50: >2.50E+4nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 3B(Human)
Genentech

LigandPNGBDBM195608(CPI-455 | US20240139197, Compound 3)
Affinity DataIC50:  1.53E+4nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 3B(Human)
Genentech

LigandPNGBDBM195608(CPI-455 | US20240139197, Compound 3)
Affinity DataIC50: >1.53E+4nMAssay Description:Inhibition of KDM3B (unknown origin) using ARTKQTAR(KMe1)STGGKAPRKQLA -NovaTagPEG-biotin/2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 3B(Human)
Genentech

LigandPNGBDBM195608(CPI-455 | US20240139197, Compound 3)
Affinity DataIC50: >1.53E+4nMAssay Description:Inhibition of KDM3B (unknown origin) using ARTKQTAR(KMe1)STGGKAPRKQLA -NovaTagPEG-biotin/2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed