BDBM195609 CPI-4203

SMILES CCc1c([nH]c2c(cnn2c1=O)C#N)-c1ccccc1C

InChI Key InChIKey=OXELDRCVUWWSFZ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 195609   

TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

LigandPNGBDBM195609(CPI-4203)
Affinity DataIC50:  248nMpH: 7.0Assay Description:Time-resolved fluorescence resonance energy transfer (TR-FRET) assays were carried out using full-length KDM5 enzymes in 384-well black ProxiPlates (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

LigandPNGBDBM195609(CPI-4203)
Affinity DataIC50:  1.50E+3nMpH: 7.0Assay Description:Time-resolved fluorescence resonance energy transfer (TR-FRET) assays were carried out using full-length KDM5 enzymes in 384-well black ProxiPlates (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

LigandPNGBDBM195609(CPI-4203)
Affinity DataIC50:  206nMAssay Description:Inhibition of KDM5A (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/1 uM 2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

LigandPNGBDBM195609(CPI-4203)
Affinity DataIC50:  206nMAssay Description:Inhibition of KDM5A (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/1 uM 2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed