BDBM4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US20240058459, Compound Sunit-inib::US9163010, Sunitinib::US9914707, SU11248
SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
InChI Key InChIKey=WINHZLLDWRZWRT-ATVHPVEESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 38 hits for monomerid = 4814
Affinity DataKi: 4nMAssay Description:Binding affinity to c-KIT (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 210nM ΔG°: -9.10kcal/molepH: 7.4 T: 25°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKi: 280nM ΔG°: -8.93kcal/molepH: 7.4 T: 25°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKi: 370nM ΔG°: -8.77kcal/molepH: 7.4 T: 25°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKi: 410nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKi: 3.80E+5nM ΔG°: -4.66kcal/molepH: 7.4 T: 25°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKi: 4.30E+5nM ΔG°: -4.59kcal/molepH: 7.4 T: 25°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKi: 5.60E+5nM ΔG°: -4.43kcal/molepH: 7.4 T: 25°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKi: 2.30E+6nM ΔG°: -3.60kcal/molepH: 7.4 T: 25°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 0.410nMAssay Description:Binding constant for KIT(V559D) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.280nMAssay Description:Binding constant for KIT(V559D,T670I) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.30nMAssay Description:Binding constant for KIT(L576P) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 43nMAssay Description:Binding constant for KIT(A829P) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 380nMAssay Description:Binding constant for KIT(D816V) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.370nMAssay Description:Binding constant for KIT kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.210nMAssay Description:Binding constant for KIT(V559D,V654A) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.280nMAssay Description:Binding constant for KIT(V559D,T670I) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.410nMAssay Description:Binding constant for KIT(V559D) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.370nMAssay Description:Binding constant for KIT kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 380nMAssay Description:Binding constant for KIT(D816V) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.710nMAssay Description:Average Binding Constant for KIT; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 0.370nMAssay Description:Binding affinity to KITMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of c-Kit autophosphorylation in human Kasumi-1 cells by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of c-Kit after 30 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Binding constant for KIT(D816H) kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant c-Kit by radiometric assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.210nMAssay Description:Binding constant for KIT(V559D,V654A) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.370nMAssay Description:Binding affinity to human KIT incubated for 1 hr by kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of human KITMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Concentration required to inhibit the activity of K+ stimulated gastric ATPaseMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant human N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) expressed in baculovirus infected...More data for this Ligand-Target Pair
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of ATP-activated recombinant human N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) expressed in baculo...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of unactivated recombinant human N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) expressed in baculovi...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) (unknown origin) expressed in baculovir...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inhibition of c-KIT (unknown origin) incubated for 30 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair