BDBM50308135 1-(4-{[4-(Dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea::CHEMBL592445::PKI-587

SMILES CN(C)C1CCN(CC1)C(=O)c1ccc(NC(=O)Nc2ccc(cc2)-c2nc(nc(n2)N2CCOCC2)N2CCOCC2)cc1

InChI Key InChIKey=DWZAEMINVBZMHQ-UHFFFAOYSA-N

Data  27 IC50  9 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50308135   

LigandPNGBDBM50308135(1-(4-{[4-(Dimethylamino)piperidin-1-yl]carbonyl}ph...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50308135(1-(4-{[4-(Dimethylamino)piperidin-1-yl]carbonyl}ph...)
Affinity DataKd:  3.5nMAssay Description:Binding affinity to human PI3Kbeta (P118 to S1070 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50308135(1-(4-{[4-(Dimethylamino)piperidin-1-yl]carbonyl}ph...)
Affinity DataIC50:  6nMAssay Description:Inhibition of wild type human PI3K p110beta using PIP2 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50308135(1-(4-{[4-(Dimethylamino)piperidin-1-yl]carbonyl}ph...)
Affinity DataIC50:  28nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate in presence of ATP incubated for 60 mins by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed