BDBM445952 US10669246, Example 4::US10968188, Example 4

SMILES Cc1ccncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1

InChI Key InChIKey=SFFSWMIVCZTNBC-YPMHNXCESA-N

Data  1 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 445952   

TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM445952(US10669246, Example 4 | US10968188, Example 4)
Affinity DataIC50:  1.97E+3nMAssay Description:ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Bovine serum albumin (BSA) and dimethylsulfoxide (DMSO) were purchased from...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM445952(US10669246, Example 4 | US10968188, Example 4)
Affinity DataIC50:  1.97E+3nMAssay Description:PDGFRα kinase activity was measured by Promega's ADP-Glo™ Assay. In this assay, Recombinant human PDGFRα (40 ng) is incubated with 5 &#...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM445952(US10669246, Example 4 | US10968188, Example 4)
Affinity DataIC50:  9.45E+3nMAssay Description:Inhibition of recombinant human PDGFRalpha assessed as luminescence using poly (4:1 Glu, Tyr) peptide as substrate incubated for 1 hr by ADP-Glo assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed