BDBM50024354 CHEMBL3330444::US10106557, Compound 2

SMILES [H][C@@]12COc3cc(ccc3N1C(=O)O[C@H]2CNC(=O)c1ccc(Cl)s1)N1CCCCC1=O

InChI Key InChIKey=JCTRHKZXDDIGIB-HOCLYGCPSA-N

Data  5 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50024354   

TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM50024354(CHEMBL3330444 | US10106557, Compound 2)
Affinity DataKi:  4.22nMpH: 7.4Assay Description:The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM50024354(CHEMBL3330444 | US10106557, Compound 2)
Affinity DataKi: >1.00E+3nMpH: 7.4Assay Description:The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...More data for this Ligand-Target Pair
In DepthDetails US Patent