BDBM4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US20240058459, Compound Sunit-inib::US9163010, Sunitinib::US9914707, SU11248
SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
InChI Key InChIKey=WINHZLLDWRZWRT-ATVHPVEESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 46 hits for monomerid = 4814
Affinity DataKd: 0.470nMpH: 7.4 T: 25°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 0.990nMpH: 7.4 T: 25°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of FLT3 by time resolved fluorescence methodMore data for this Ligand-Target Pair
Affinity DataKd: 0.470nMAssay Description:Binding affinity to FLT3More data for this Ligand-Target Pair
Affinity DataKd: 0.470nMAssay Description:Binding affinity to FLT3 catalytic domain by KinomeScan kinase binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.220nMAssay Description:Binding constant for FLT3(K663Q) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.410nMAssay Description:Binding constant for FLT3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 4.30nMAssay Description:Binding constant for FLT3(D835H) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 2.30nMAssay Description:Binding constant for FLT3(D835Y) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 2.40nMAssay Description:Binding constant for FLT3(N841I) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Binding constant for FLT3(R834Q) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 4.30nMAssay Description:Binding constant for FLT3(D835H) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.990nMAssay Description:Binding constant for FLT3(ITD) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 2.30nMAssay Description:Binding constant for FLT3(D835Y) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 2.40nMAssay Description:Binding constant for FLT3(N841I) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.800nMAssay Description:Average Binding Constant for FLT3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 0.470nMAssay Description:Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.90nMAssay Description:Inhibition of FLT3 autophosphorylation in human RS4-11 cells after 2 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of FLT3 autophosphorylation in human RS4-11 cells by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataKd: 0.990nMAssay Description:Binding constant for FLT3(ITD) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.800nMAssay Description:Inhibition of FLT3 by cellular assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.470nMAssay Description:Binding constant for FLT3 kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Inhibition of FLT3 by ELISA-based kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) phosphorylation measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of wildtype FLT3 (unknown origin) phosphorylation measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataKd: 4.30nMAssay Description:Binding affinity to human FLT3 D835H mutant expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataKd: 0.990nMAssay Description:Binding affinity to human FLT3 ITD mutant expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataKd: 0.430nMAssay Description:Binding affinity to non-auto-inhibited form of wild type human N-terminal GST-tagged FLT3 expressed in baculovirus expressionMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of wild type recombinant GST-tagged FLT3 (Y567 to S993 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells using...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 30 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) incubated for 30 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) incubated for 30 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of FLT3-D835Y autophosphorylation in human MV4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of FLT3 autophosphorylation in human RS4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of FLT3-ITD autophosphorylation in human MV4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of FLT3-ITD (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 1 hr in presence of ATP by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of FLT3-ITD mutant phosphorylation in human MV4-11 cell incubated for 2 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of wild type FLT3 (unknown origin) phosphorylation in human RS4-11 cellsMore data for this Ligand-Target Pair