BDBM19149 CHEMBL98::N-hydroxy-N'-phenyloctanediamide::SAHA::US10011611, SAHA::US10188756, Compound SAHA::US11207431, SAHA::US11505523, Compound SAHA::US9115116, SAHA::US9353061, SAHA::US9428447, SAHA::US9695181, Vorinostat::Vorinostat::Zolinza::cid_5311::suberoylanilide hydroxamic acid
SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
InChI Key InChIKey=WAEXFXRVDQXREF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 19149
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Southern Research Institute
Curated by PubChem BioAssay
Southern Research Institute
Curated by PubChem BioAssay
TargetHistone deacetylase 6(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataEC50: 1.03E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataEC50: 1.00E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISAMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
National Institutes Of Health Chemical Genomics Center
Curated by ChEMBL
National Institutes Of Health Chemical Genomics Center
Curated by ChEMBL
Affinity DataEC50: 3.55E+4nMAssay Description:Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysisMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Rattus norvegicus)
National Institutes Of Health Chemical Genomics Center
Curated by ChEMBL
National Institutes Of Health Chemical Genomics Center
Curated by ChEMBL
Affinity DataEC50: 2.50E+3nMAssay Description:Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysisMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
National Institutes Of Health Chemical Genomics Center
Curated by ChEMBL
National Institutes Of Health Chemical Genomics Center
Curated by ChEMBL
Affinity DataEC50: 2.51E+4nMAssay Description:Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataEC50: 399nMAssay Description:Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assayMore data for this Ligand-Target Pair
Affinity DataEC50: 180nMAssay Description:Inhibition of HDAC in human cell lysates using fluoro-substrate peptide/fluoro-deacetylated peptide as substrate incubated for 20 mins measured at 1 ...More data for this Ligand-Target Pair
3D Structure (crystal)TargetHistone deacetylase 6(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataEC50: 22nMAssay Description:Inhibition of HDAC6 in human HeLa cells assessed as inhibition of tubulin deacetylation incubated for overnight by cELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 550nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
TargetProtein Tat(Human immunodeficiency virus type 1 (isolate HXB2 ...)
The Walter and Eliza Hall Institute For Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute For Medical Research
Curated by ChEMBL
Affinity DataEC50: 2.30E+3nMAssay Description:Activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as...More data for this Ligand-Target Pair
Affinity DataEC50: 1.68E+3nMAssay Description:Inhibition of HDAC in human MeT-5A cells assessed as increase in transfected YFP fused histone H3 acetylation treated at 8 hrs after YFP fused H3 tra...More data for this Ligand-Target Pair
Affinity DataEC50: 1.60E+3nMAssay Description:Inhibition of class 1 HDAC in human Jurkat model of HIV latency assessed as reactivation of HIV latency incubated for 20 hrs in presence of 5% NHS by...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Binding affinity to recombinant human full length His-tagged BAX expressed in Escherichia coli BL21 (DE3) cells preincubated for 30 min followed by F...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataEC50: 430nMAssay Description:Inhibition of HDAC6 in human MCF7 cells assessed as increase in acetylated alpha-tubulin at Lys40 residue incubated for 3 hrs by ELISAMore data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 2 hits for monomerid = 19149
ITC DataΔG°: -8.36kcal/mole −TΔS°: 2.42kcal/mole ΔH°: -10.9kcal/mole logk: 1.36E+6
T: 25.00°C
T: 25.00°C
ITC DataΔG°: -8.36kcal/mole −TΔS°: 0.0519kcal/mole ΔH°: -8.96kcal/mole logk: 2.21E+6
pH: 7.5 T: -248.15°C
pH: 7.5 T: -248.15°C