BDBM50035179 Agomelatine::CHEMBL10878::N-[2-(7-Methoxy-naphthalen-1-yl)-ethyl]-acetamide::N-[2-(7-Methoxy-naphthalen-1-yl)-ethyl]-acetamide(Agomelatine)::S 20098::US10781182, Compound IA2-76::US11091445, Compound code IA2-76
SMILES COc1ccc2cccc(CCNC(C)=O)c2c1
InChI Key InChIKey=YJYPHIXNFHFHND-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50035179
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 1.40nMAssay Description:Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 0.180nMAssay Description:Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 0.100nMAssay Description:Agonist activity at human human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 1.60nMAssay Description:Agonist activity at human human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 0.180nMAssay Description:Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 1.40nMAssay Description:Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 8.89E+4nMAssay Description:Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-be...More data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 0.180nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Functional activity against melatonin receptor in lightening Xenopus laevis tadpole skinMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 1.60nMAssay Description:Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 0.210nMAssay Description:Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 5.80E+6nMAssay Description:Agonist activity at human MT1 receptor expressed in HEK293 cells by Fluo-8 based calcium assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 1.73E+7nMAssay Description:Agonist activity at human MT2 receptor expressed in HEK293 cells by Fluo-8 based calcium assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 2.65E+4nMAssay Description:Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-be...More data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 0.100nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 1.56nMAssay Description:Agonist potency determined by [35S]-GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 0.100nMAssay Description:Agonist potency determined by [35S]-GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BMore data for this Ligand-Target Pair