BDBM21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656
SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
InChI Key InChIKey=MPVGZUGXCQEXTM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 58 hits for monomerid = 21079
Affinity DataIC50: 16nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.5 T: 22°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Human)
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of FGFRMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of FGRMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of CDC2 using 5 to 10 ATP umol/LMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of FLT1 by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of FLT3 by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of CSF1R by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of c-Kit by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of AKT using 5 to 10 ATP umol/LMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of KDR (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of c-Kit by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant GST-tagged VEGFR2 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 760nMAssay Description:Inhibition of recombinant GST-tagged Aurora A expressed in Sf9 insect cells after 90 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of GST-tagged FLT3 expressing wild type kinase domain expressed in Sf9 insect cells after 4 hrs by Kinase-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant GST-tagged VEGFR1 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of wild type GST tagged FLT3 kinase (567 to 993) (unknown origin) transfected in insect sf9 cells after 4 hrs by wallac counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 760nMAssay Description:Inhibition of recombinant GST tagged Aurora A kinase (123 to 401) (unknown origin) transfected in insect sf9 cells after 90 mins by wallac counting a...More data for this Ligand-Target Pair
Affinity DataIC50: 760nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of wild type FLT3More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Human)
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 15nMAssay Description:Inhibition of PDGFRalpha (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of VEGFR2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition in presence of A...More data for this Ligand-Target Pair
Affinity DataIC50: 5.48E+3nMAssay Description:Inhibition of FGFR1 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition in presence of AT...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human PDGFRbeta using biotin labeled substrate after 1 hr by HTFR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of human KDR using biotin labeled substrate after 1 hr by HTFR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human VEGFR2 expressed in sf9 cells after 1.5 to 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of CDK8 (unknown origin) expressed in human 7dF3 cells harboring TCF/LEF WNT-reporter assessed as inhibition of Wnt pathway after 24 hrs b...More data for this Ligand-Target Pair
Affinity DataIC50: 5.17E+3nMAssay Description:Inhibition of CDK8 in human LS174T cells harboring TCF/LEF WNT-reporter assessed as inhibition of Wnt pathway after 24 hrs by luciferase reporter gen...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Human)
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 190nMAssay Description:Inhibition of FLT4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair