BDBM32546 arylsulfonylpiperazine, 18
SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1
InChI Key InChIKey=SYQSWNRTYTVMSS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 32546
Affinity DataIC50: 13nM EC50: 547nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding
Curated by ChEMBL
Shanghai Pharmaceutical Holding
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Enzyme assays were performed using purified recombinant mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine en...More data for this Ligand-Target Pair