BDBM453275 BDBM453327::US10730826, Compound 1a-non-racemic::US10730826, Compound 1a-racemic::US11325884, Compound 1

SMILES NCCCC[C@H](NC(=O)C1CCCC1)C(=O)COc1c(F)ccc(F)c1F

InChI Key InChIKey=OLIMBXKACVCIMM-HNNXBMFYSA-N

Data  25 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 453275   

TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50: <0.0500nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

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TargetCathepsin Z(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

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TargetCathepsin S(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50:  2.95E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetCathepsin K(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50:  170nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetProcathepsin L(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50:  4.68E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetPro-cathepsin H(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50:  560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50: <0.0500nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sid

In DepthDetails US Patent

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TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50: <0.0500nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

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TargetCathepsin K(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50:  117nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

In DepthDetails US Patent

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TargetPro-cathepsin H(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50:  560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

In DepthDetails US Patent

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TargetCathepsin B(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50:  380nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

In DepthDetails US Patent

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TargetCathepsin F(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50:  6.10E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetProcathepsin L(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50:  4.68E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

In DepthDetails US Patent

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TargetCathepsin L2(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

In DepthDetails US Patent

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TargetCathepsin S(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

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TargetCathepsin Z(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

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TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50: <0.0500nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sid

In DepthDetails US Patent

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TargetCathepsin K(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50:  117nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

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TargetPro-cathepsin H(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50:  560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI

TargetCathepsin B(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50:  380nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI

TargetCathepsin F(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50:  6.10E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

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TargetProcathepsin L(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50:  4.68E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

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TargetCathepsin L2(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI

TargetCathepsin S(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI

TargetCathepsin B(Human)
Cortexyme

US Patent

LigandBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)Copy SMILESCopy InChI

Affinity DataIC50:  380nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI