BDBM50265157 (6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamide::CHEMBL497985

SMILES CN1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)NO

InChI Key InChIKey=HJNKYGBTSGQBDU-HOCLYGCPSA-N

Data  10 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50265157   

TargetInterstitial collagenase(Homo sapiens (Human))
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataIC50:  2.05E+3nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 9(Homo sapiens (Human))
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of ADAM9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataIC50:  97nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 33(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataIC50:  4.13E+3nMAssay Description:Inhibition of ADAM33More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-15(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MMP15More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataIC50:  564nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed