BDBM21492 4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline::CHEMBL261454::LY364947::US11759530, Compound Table1.1::US9138393, LY-364947::US9144538, LY-364947

SMILES c1[nH]nc(c1-c1ccnc2ccccc12)-c1ccccn1

InChI Key InChIKey=IBCXZJCWDGCXQT-UHFFFAOYSA-N

Data  18 IC50  2 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 21492   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL

LigandBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Copy SMILESCopy InChI

Affinity DataKd:  5nMAssay Description:Dissociation constant for TGF-beta receptor type IMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankMCE
MMDBPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

LigandBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Copy SMILESCopy InChI

Affinity DataKd:  1.87E+3nMAssay Description:Binding affinity to human ARGMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankMCE
MMDBPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI